Erin Allman‑Updyke and Erin Welsh (This Podcast Will Kill You hosts) - primarily Erin Allman‑Updyke or Erin Welsh
speaker
917 appearances
1 recordings
1 series
first heard Jul 2026
last heard 28 Jul
Erin Allman‑Updyke and Erin Welsh (This Podcast Will Kill You hosts) - primarily Erin Allman‑Updyke or Erin Welsh’s voice in public audio — every appearance, attributed to the second.
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recordings per month · last 12 monthsRecordings per month over the last 12 months — 1 in all, peaking in Jul 2026 with 1.
Appearances
Yeah.
This discovery, Brown and Goldstein's discovery of the LDL receptor, it transformed the field.
So much so that it earned them a Nobel Prize in 1985.
Because not only did it explain why people with familial hypercholesterolemia develop cardiovascular disease, it clarified how our cells regulate cholesterol, specifically LDL, and why disease happens when that regulation goes awry.
So it was a major, major step forward in solidifying the cholesterol-heart disease link, and it opened these different pathways to treatment.
Ding, ding, ding.
Can we do something about this receptor?
Yeah.
Did it end the cholesterol wars?
Not necessarily.
It really didn't.
The debate continued, but it had lost a lot of steam.
The advent of cholesterol-lowering drugs like statins changed the conversation by turning cardiovascular disease from a disease to manage into one to treat, even prevent, potentially.
But as we'll see next week, their use has also been met with a hefty amount of skepticism.
And so the cholesterol wars really continue through today.
It is so interesting, Erin, how much, like, it...
It's really hard, I think, to find someone who doesn't at least agree that high levels of cholesterol put you at high risk for heart disease.
Yeah.
And yet there still is so much like about what you do about it or what we shouldn't do about it or what your diet effect might be.
Like it's.
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