Erin Allman‑Updyke
speaker
983 appearances
2 recordings
1 series
first heard Sep 2026
last heard 4d ago
Erin Allman‑Updyke’s voice in public audio — every appearance, attributed to the second.
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recordings per month · last 12 monthsRecordings per month over the last 12 months — 2 in all, peaking in Sep 2026 with 2.
Appearances
Yes.
Okay, let's get into it.
Yeah.
Um, of course, the short answer to how does this work is that we still don't really know.
We don't really know.
And that's in part because we don't know the biological mechanisms of so many of these disorders that we can treat with ECT.
Right.
But that doesn't mean we don't have hypotheses.
There are a few main hypotheses as to how ECT works in our brains.
The first is that we see
Substantial increases and changes in a bunch of our neurotransmitters.
These are friends that we know well from other episodes like dopamine, serotonin, et cetera.
We also see big changes in GABA, which is an inhibitory neurotransmitter.
And what's interesting about GABA is that we think, well, maybe this is just like a neurotransmitter effect, but also GABA is involved in seizures.
Because it's like an inhibitory neurotransmitter, if GABA levels are low, then your seizure threshold is lower.
And we know that ECT actually raises the seizure threshold.
So during a course of ECT, uh seizures tend to get shorter.
And sometimes we have to go up on that electricity dose in order to have an actual seizure because our threshold is rising with increasing treatments.
So there's some thought that maybe it's actually a GABA-related anti-convulsant effect that somehow is how ECT is working.
That's an anti convulsive effect.
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