Erin Allman‑Updyke
speaker
983 appearances
2 recordings
1 series
first heard Sep 2026
last heard 4d ago
Erin Allman‑Updyke’s voice in public audio — every appearance, attributed to the second.
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recordings per month · last 12 monthsRecordings per month over the last 12 months — 2 in all, peaking in Sep 2026 with 2.
Appearances
And then why is that also affecting all these other things?
There's some involvement there that we don't know.
We also know that ECT has induces really big fluctuations in a whole bunch of hormones that our brain releases.
So inside of our brain, there's these areas called the hypothalamus and the pituitary gland.
We've talked about these in other episodes.
And these produce hormones that go throughout our body and interact with a whole bunch of other organs like our thyroid, our ovaries, our testes, our adrenal glands.
And what we see after
ECT is increases in a lot of these hormones that are produced by the hypothalamus and the pituitary, things like prolactin, uh ACTH, which stimulates the release of cortisol.
We also see increases in TSH and just a bunch of changes that happen in our hormones.
How does this then directly cause improvements in symptoms?
We don't know, but we see these changes from ECT.
And finally, there's also evidence, and this one is so interesting, Erin.
ECT induces what's called neurogenesis, which really means like structural brain changes in various parts in various different cell types.
And this, we think, is mostly mediated by this really interesting compound called BDNF, or brain derived neurotrophic factor.
And this actually induces neurotrophic.
genesis.
And so we think maybe it's down to that.
Maybe it's some combination of all of these different things that are all happening as a result of ECT.
And we don't necessarily have like a one-to-one mechanism of like this is the thing that helps with depression.
This is the thing that helps with suicidality.
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