Ian Sample

speaker

2,123 appearances 29 recordings 3 series first heard Apr 2026 last heard 4d ago

Ian Sample’s voice in public audio — every appearance, attributed to the second.

Trend

recordings per month · last 12 months

Recordings per month over the last 12 months — 29 in all, peaking in Jun 2026 with 8.

Appearances

newest first · ▶ plays the moment

Science Weekly · Can a world-first gene therapy reverse ageing? · 16 Jul 2026 podcast

And this is called epigenetic patterning. matched

And again, as our cells age, what's called the epigenome, the epigenetics changes. matched

And that also affects how well cells function. matched

So most of the cells in your body carry DNA. matched

Not all of them, but the vast majority, OK? matched

Now, that code is the same in all of those cells. matched

So that raises a question. matched

Well, if the code's the same in all the cells, how come I've got all these different types of cells, specialised cells doing different things? matched

We've got neurons, we've got muscle cells, we've got liver cells. matched

And the answer is epigenetics. matched

So if you go inside a cell and you look at the DNA, the DNA will have a pattern of chemical tags running along it, and they will tell the cell which genes to read and which ones to leave. matched

That pattern of epigenetics across the DNA is really what determines what that cell becomes. matched

So whether it becomes a heart cell, a liver cell, or a muscle cell. matched

Now, your epigenome, as it's called, this pattern, is primarily set when you're an embryo, but it's not fixed. matched

There's all sorts of things that can feed into how that sort of epigenome evolves over your lifetime. matched

And this is things like exposure to hormones, estrogen, testosterone. matched

It's things like your diet. matched

It can be even things like the pollution you're exposed to and even how much exercise you get. matched

Now, these changes build up over time, but also as we age, the epigenetics gets messed up a little bit and the cells don't function as properly because this controlling structure over the top isn't doing the job it should be doing. matched

And it's almost like, you know, a nice analogy is it's like the fluff on a record that it sort of just builds up to the point that the needle skips and it's not reading the grooves in the record properly, if you like. matched

Showing 1161–1180 of 2,123 · page 59 of 107