James Bullen
speaker
1,082 appearances
27 recordings
1 series
first heard Nov 2017
last heard Feb 2020
James Bullen’s voice in public audio — every appearance, attributed to the second.
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Appearances
Health Report · Mini-organs, sex in aged care and mental health at the GP's office · 23 Sep 2019
podcast
Some are common, some are exceptionally rare, and your gene mutation can predict how well you respond to new drug treatments, like the one Ruby is using, and whether you're eligible for subsidies, because these drugs are expensive.
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And that's where Organoids enter the picture.
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Dr.
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Shaffer Waters is a senior research associate at the Molecular and Integrative Cystic Fibrosis Research Centre at UNSW and Sydney Children's Hospital.
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Through a microscope, these organoids appear as clustered overlapping spheres.
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They're a little like bubbles in a soft drink.
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And once you've grown one, you can cultivate others.
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It's like a plant, Dr.
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Waters says.
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Organoids copy the genetics of the person they've been grown from.
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That makes them ideal for answering questions like whether someone will respond well to a particular cystic fibrosis drug.
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The scientists dose the spheres, these bubbles of cells, with different drugs to see what works.
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Dr.
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Waters showed me some of the tests they'd done on healthy gut organoids and gut organoids made from people with cystic fibrosis.
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When drugs are given to healthy organoids, it helps the protein that's broken work properly, and those soft drink bubbles dance and grow.
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But when the drug is given to organoids derived from people with cystic fibrosis, nothing happens.
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But sometimes the organoids do swell, and that's an indication that the drug will help the cystic fibrosis patient, that they're a responder.
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Right.
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So patients can have the same mutations but the drug can have different effects on them and and that determines whether they're responsive or not.
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Professor Adam Jaffy But while Europe is starting to screen patients for CF drugs on the basis of organoid testing, we're not ready for that in Australia yet.
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Showing 241–260 of 1,082 · page 13 of 55
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