Jason Karlawish

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1,378 appearances 5 recordings 1 series first heard Feb 2021 last heard Dec 2023

Jason Karlawish’s voice in public audio — every appearance, attributed to the second.

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I think you're I think that's the conceptual issue that the field's struggling with.

I do, which is is amyloid a abnormality along a pathophysiologic continuum such that

amyloid like hemog like glycosylated hemoglobin.

We all have a level of glycosylated hemoglobin.

If we didn't we'd be dead.

But there's some level of like oscillated hemoglobin which very neatly correlates with abnormal glucose tolerance, which is diabetes, okay?

Or is amyloid like mitotic figures spreading beyond the basement membrane by definition pathologic?

That is cancer.

And I don't get in these new criteria where is amyloid?

Is it a point along a continuum like hemoglobin A one C?

That is to say there's a level of amyloid which would be acceptable as part of just our physiology?

Or is it mitotic figures?

the mere presence is disease.

I don't know.

I cannot tell from the new criteria.

If the actuarial data

That described beta amyloidosis in the brain.

uh was cu sufficiently compelling.

That of the likelihood of developing dementia.

You could make the argument that I'll call back the disease.

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