Jason Karlawish
speaker
1,378 appearances
5 recordings
1 series
first heard Feb 2021
last heard Dec 2023
Jason Karlawish’s voice in public audio — every appearance, attributed to the second.
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period.
And of course the all the things that flow from that that you're gesturing to heather follow, namely the burden of that label on someone's um sense of self efficacy, how they're treated by other people, in a word, the stigmas that surround the disease.
So I I think
I'm willing though to separate those very important social and cultural issues from
what does the biology and the science tell us?
I just don't think that the biology and science that surrounds beta amyloidosis alone suff is sufficient to rise the level of I'm gonna call it a disease.
I think that the actual data are compelling that elevated amyloid alone in some individuals can lead to downstream d dementia.
But I think defining a disease on actual basis alone is very difficult for reasons related to cohort bias, et cetera.
The strongest evidence I think to help define a disease on the basis of, if you will, a factor only, like lipids, for example, elevated lipids, is the results of an experiment that if I reduce that, if I intervene
in a i I can change the natural history of of outcome.
And that's what got li hyperlipidemia turned into hyperlipidemia.
Same so too sistolic hypertension in elderly people, clinical trials.
I haven't yet seen those clinical trials with beta amyloid in asymptomatic individuals to allow me to reach that conclusion.
So I'll stop there.
Yeah, so I don't say if I put my cards on the table, but someone with cognitive impairment, whether it's causing inefficiencies or disabilities in daily living, otherwise known as MCI or dementia.
I think the role of biomarkers is very clear to help sort out what's causing that problem.
And if it had all that amyloid and meet other criteria, there was even a treatment treatment's now available.
Okay.
That that's that.
Um, I think though, once we push into the space of someone who
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