Jason Karlawish
speaker
1,378 appearances
5 recordings
1 series
first heard Feb 2021
last heard Dec 2023
Jason Karlawish’s voice in public audio — every appearance, attributed to the second.
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Appearances
А сам тайс амблои вас ток-то.
Cancer.
You know, mitotic figures was spread beyond the basement membrane and necrosis.
That is abnormal, that is pathophysiology.
Other times amyloid was talked about like hemoglobin A one C.
Glycosylated hemoglobin is a measure of physiology.
We all have a glyclosylated hemoglobin level, but it can go above a certain level that then becomes pathologic based on criteria of cutoff that would then define diabetes.
And so I I can't tell is amyloid in alone a risk factor like hemoglobin A one C that crosses a threshold or is amyloid alone in the brain like a tumor?
It is by definition pathology.
There's just an normal about mitotic figures with necrosis and spread beyond the basement membrane.
That is cancer.
And I I think what it comes down to is what measure of amyloid is that?
Is it the plaques?
Is it the toxic oligomers which we cannot measure?
Is it the monomers which we cannot measure?
And so
I that I think is a is is where we're struggling, and I feel that that early definition of amyloid positive is Alzheimer's.
I I don't get the conceptual model.
Is it tumor or is it hemolobin A1C?
And those are very different concepts.
Showing 401–420 of 1,378 · page 21 of 69
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