Jason Karlawish
speaker
1,378 appearances
5 recordings
1 series
first heard Feb 2021
last heard Dec 2023
Jason Karlawish’s voice in public audio — every appearance, attributed to the second.
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Appearances
And indeed, the latest sets of studies now have made an emphasis on you have to have elevated amyloid and evidence of tau spread in order to get the drug to be tested.
And indeed many of us thought that the next study that should be done with Adi Canamab was just that.
They didn't have Tau Tracer available when they started the studies years a couple of years ago in Gauge and Emerge.
And only later did they add Tau Tracer.
And so you'll see this data that they put out.
Where they have like 15 subjects who had TAU scans in the in the phase three trials and they report data out from that.
You know, fifteen subjects with TAU scans.
You know, you could use those their their first names for a uh wordless learning task to test whether they pr transition to dementia.
My my my point being, you know, th it just wasn't a study that was designed in the way that I think now we think these studies need to be designed to establish do these drugs make a difference or do we need to move on to a different mechanism?
And I think that's what makes the field so furious.
And I will say
And then I'll I'll I'll cut well I'll take a drink of tea.
Z
I can't amongst the crowd in the Alzheimer's field that I hang out with.
I have not been able to find
folks other than those who were in the sort of clinical trial world who've been very public s even before approval.
Who view this approval as a the breakthrough.
Most of them just slap their foreheads and say, I can't believe this happened.
Many of them won't speak about it because, you know, with politics, et cetera.
But I will say people who I deeply respect and are just shake their heads and say this was a bridge too far too soon and they are really angry about what's happened.
Showing 901–920 of 1,378 · page 46 of 69
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