Jason Karlawish
speaker
1,378 appearances
5 recordings
1 series
first heard Feb 2021
last heard Dec 2023
Jason Karlawish’s voice in public audio — every appearance, attributed to the second.
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Appearances
I I want to see results of studies like the AHEAD study, um, Trailblazer Three.
These are studies testing drugs in individuals who are cognitively unimpaired and yet have markers of um uh elevated amyloid and or also Tau.
Those results will be very compelling to have me change my view.
Well, and you're
I'm I'm I'm with you on the observational data, but I think observational data alone to define a disease are very slender read.
Having said that.
Um a clinic clinical trials have their faults as well, but they're very compelling experiments.
To validate causation.
And that's what I find very compelling.
and I'm willing all those issues that Law has raised
I'm willing I think the A B forty five and related amyloid scans and the Tau scan, the one that is commercially available, I think the data support their use.
uh in individuals who have uh clinical disease.
Okay.
Uh with all the caveats around the uh potential.
I think what you're getting at Lon though is
There's still enough noise in the system to say it is a bold reach.
To use those results in individuals.
of younger ages who are asymptomatic and call that a disease.
I think that's where I think we're struggling.
Welcome to the world welcome to the world that we live in.
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