Jens Juul Holst

speaker

287 appearances 1 recordings 1 series first heard May 2026 last heard 4 May

Jens Juul Holst’s voice in public audio — every appearance, attributed to the second.

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Recordings per month over the last 12 months — 1 in all, peaking in May 2026 with 1.

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Discovery · The Life Scientific: Jens Juul Holst · 4 May 2026 podcast

It came from Stockholm.

It was called GIP.

peptides.

I mean, these are basically molecular chains of amino acids.

Yes, short chains.

And there was one coming up from Stockholm, which was demonstrated to be able to stimulate insulin secretion in people.

But for various reasons, we could show that this was not the substance that was responsible for our hypoglycemia patients.

So there had to be another one.

This was clear.

And we found some cells in the gut

that were illuminating with antibodies against glucagon.

And glucagon is a hormone from the pancreas that is normally regulating blood glucose.

And it was ridiculous that glucagon should be found in the gut all of a sudden.

But we eventually isolated the peptides from those cells and found out what it was.

And it was a peptide that contained glucagon in the middle.

So we found out that this was actually the precursor of glucagon because we could also find it in the pancreas and all the bits and pieces there.

So, the interesting thing was, of course, to find out what was in the rest of the molecule.

That was an American who found out that, a guy called Graham Bell, who in 1983 was able to pull out a gene sequence.

And we found in that DNA sequence there was coding for something that looked like glucagon.

Actually, there were two stretches that looked like glucagon, both of them.

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