Jens Juul Holst

speaker

287 appearances 1 recordings 1 series first heard May 2026 last heard 4 May

Jens Juul Holst’s voice in public audio — every appearance, attributed to the second.

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Discovery · The Life Scientific: Jens Juul Holst · 4 May 2026 podcast

And that's how Novo Nordisk, for instance, became interested.

And of course, we also demonstrated in 96 and 97, 8, that it also inhibited food intake in people.

And that, of course, was also very, very interesting.

So we started doing studies and tried to see what happened.

And sure enough, we could inhibit appetite and we could inhibit food intake with infusions of GLP-1 in people.

Can you explain what these issues were?

I can easily explain that.

So what we found immediately was that if we gave them intravenous infusions into the bloodstream, that worked.

But if we gave them just a single injection, it didn't work.

Why not?

Because the peptide was eliminated from the body immediately almost.

So it has what we call a half-life.

It means that half of what you have in the body is eliminated within two minutes.

So it disappears during very, very few minutes.

It completely disappears.

And you can't treat people with a peptide that is eliminated so quickly.

We found the reason for it, and that was an enzyme.

But we also found out that if you could inhibit that enzyme, you could actually make the hormone GLP-1 survive for a longer time.

But that was one of the problems, the very short survival time.

So we tried that, of course.

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