Luke O'Neill

speaker

4,575 appearances 24 recordings 2 series first heard Apr 2026 last heard 5d ago

Luke O'Neill’s voice in public audio — every appearance, attributed to the second.

Trend

recordings per month · last 12 months

Recordings per month over the last 12 months — 24 in all, peaking in Jul 2026 with 6.

Appearances

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Show Me the Science with Luke O'Neill · The Science of Cell Death · 13 Aug 2026 podcast

And y if you go back about fifty years, uh or even forty years, when I first began as a biochemist, this wasn't studied at all. voice-verified

The view was cells died. voice-verified

Die, hard luck, and that's the end of that, and they get replaced. voice-verified

And it was also known that certain things kill cells. voice-verified

So poisons, for instance, um will kill a cell, clearly. voice-verified

You know, if you put a cell in acid in a lab, it'll die, you know, and this is felt to be sort of a consequence of just sort of nonspecific injury, if you like, and nobody really thought it was that interesting. voice-verified

And it was quite a kind of niche area to study, but then it begins to take off. voice-verified

And the reason why I take off. voice-verified

Takes off is some scientists begin to realize that there's something specific going on in certain situations when cells die. voice-verified

And one area is development. voice-verified

So when a when a fetus or a new organism is developing, very often tissues will grow and then they'll recede a bit and grow again, and that's because the cells are dying. voice-verified

But they're dying in a very ordered way. voice-verified

Because the problem is if a cell explodes, kind of non-specifically explodes, that can be dangerous. voice-verified

Damaging to a tissue because it's releasing all its contents and that's noxious, right? voice-verified

So if you want to control cell death in a way, uh you will have to make sure that doesn't happen. voice-verified

A great example in us humans is, and I bet you don't know this, that when we're developing in the womb, we've webs. voice-verified

Our ancestors remember were amphibious creatures, and uh phylogeny recapitulates, ontogeny is the great phrase. voice-verified

But the the webs die right between our fingers and they get voice-verified

Eaten away. voice-verified

And that's control cell death in that web structure between your fingers. voice-verified

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