Luke O'Neill

speaker

4,575 appearances 24 recordings 2 series first heard Apr 2026 last heard 5d ago

Luke O'Neill’s voice in public audio — every appearance, attributed to the second.

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recordings per month · last 12 months

Recordings per month over the last 12 months — 24 in all, peaking in Jul 2026 with 6.

Appearances

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Show Me the Science with Luke O'Neill · The Science of Cell Death · 13 Aug 2026 podcast

So the caspases get triggered, say in that web structure. voice-verified

Between your fingers, they notice these cuspaces are getting turned on and they're chopping up the cells in a very ordered way. voice-verified

You're dismantling a cell without causing all the problems. voice-verified

A good analogy uh allergy will be if you blow up a block of flats, say, if you blow it up and it collapses to the ground, it's horrendous with the dust and the destruction. voice-verified

If you go into each flat and carefully dismantle it and package it away, you don't get all that destruction. voice-verified

And it makes sense because you don't want the surrounding. voice-verified

Surrounding tissue being destroyed if your limbs are developing, say, and that's example. voice-verified

So this ordered destruction gets discovered, and it's a remarkable discovery really. voice-verified

When I was a student, this hadn't been discovered. voice-verified

So to watch this discovery of caspases was really interesting. voice-verified

And I know the scientist who named them. voice-verified

His name is Guy Salvison, and I worked in Cambridge, and he had been in the lab that I was in Cambridge working on these enzymes. voice-verified

And he coined the term cas base guy. voice-verified

He was the first to voice-verified

characterize them. voice-verified

Another very interesting part of the history was uh there were st there were scientists studying worms called nematodes, tiny worms, and they noticed that some cells were dying during development of a nematode. voice-verified

And guess what? voice-verified

It was caspases as well who were being triggered in those nematodes. voice-verified

So all through nature there are caspases and they control death of cells in different contexts, in this main context is in development. voice-verified

Now where else do we see apoptosis? voice-verified

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