Luke O'Neill

speaker

4,575 appearances 24 recordings 2 series first heard Apr 2026 last heard 5d ago

Luke O'Neill’s voice in public audio — every appearance, attributed to the second.

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recordings per month · last 12 months

Recordings per month over the last 12 months — 24 in all, peaking in Jul 2026 with 6.

Appearances

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Show Me the Science with Luke O'Neill · The Science of Cell Death · 13 Aug 2026 podcast

In your skin, they're dying as well. voice-verified

Now remember, if you don't do it properly and the cell explodes, it will damage your tissue. voice-verified

And it causes inflammation, because all the tissue gets irritated if a cell explodes, like the you know, the tarot block collapsing. voice-verified

So you've got to be very careful and make sure it's working normally, and you can see how evolution again would have built this up. voice-verified

And there was a huge amount of work on apoptosis. voice-verified

Now, then I'm sure Jared asked me because he he knows about this, I betcha. voice-verified

That was the first type of cell death that was described. voice-verified

Then next thing then, another type of cell death called necroptosis gets discovered. voice-verified

And that's a separate type of cell death. voice-verified

Now it turns out that necroposis is actually a bit more inflammatory. voice-verified

So for example, if you injure a tissue through tr through trauma, say, or burns, or if you cut off the blood supply, those cells are not dying nonspecifically. voice-verified

Again, a special pathway is triggered involving things called rip Ks. voice-verified

Now there's another jargon term for you, but the RIPK pathway gets triggered in this situation, and that causes the voice-verified

This type of cell death called necroptosis. voice-verified

Now that's a bit more inflammatory. voice-verified

And the cell now is really exploding, I suppose, to some extent, and driving inflammation. voice-verified

Now you might want that to bring in repair, because remember, inflammation is meant to restore our bodies. voice-verified

It happens to when you get injured to cause repair to happen. voice-verified

You need a bit of action going on basically to trigger the repair response. voice-verified

And apoptosis doesn't cause that. voice-verified

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