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Matthew Schrag

👤 Speaker
148 total appearances

Appearances Over Time

Podcast Appearances

Freakonomics Radio
671. Why Has There Been So Little Progress on Alzheimer’s Disease?

So what you're talking about is a guy who ended his scientific career, in effect.

Freakonomics Radio
671. Why Has There Been So Little Progress on Alzheimer’s Disease?

Well, we'll never know because they never released any of the particulars, except to say that they had asked for journals to consider retracting other Lesney articles.

Freakonomics Radio
671. Why Has There Been So Little Progress on Alzheimer’s Disease?

Now, the initial story, this seminal paper in Nature that was influential in the field of Alzheimer's disease, and I would argue, and I think many people agree, had a very, very high degree of importance in moving the field forward.

Freakonomics Radio
671. Why Has There Been So Little Progress on Alzheimer’s Disease?

This paper was retracted, ultimately.

Freakonomics Radio
671. Why Has There Been So Little Progress on Alzheimer’s Disease?

I focused in on about 50 who were both influential and who seemed to be people who needed a closer look.

Freakonomics Radio
671. Why Has There Been So Little Progress on Alzheimer’s Disease?

Probably the most interesting one is this guy, Eliezer Maslia, who was previously the head of the Division of Neuroscience for the National Institute on Aging.

Freakonomics Radio
671. Why Has There Been So Little Progress on Alzheimer’s Disease?

This guy was overseeing a budget of about $2.7 billion per year.

Freakonomics Radio
671. Why Has There Been So Little Progress on Alzheimer’s Disease?

And this guy,

Freakonomics Radio
671. Why Has There Been So Little Progress on Alzheimer’s Disease?

made him one of the most influential people in the world, by far, to steer the agenda of neuroscience research, because this is the biggest funder worldwide for this work.

Freakonomics Radio
671. Why Has There Been So Little Progress on Alzheimer’s Disease?

He, for decades, had been a researcher at the University of California in San Diego.

Freakonomics Radio
671. Why Has There Been So Little Progress on Alzheimer’s Disease?

He became an eminent scientist in both

Freakonomics Radio
671. Why Has There Been So Little Progress on Alzheimer’s Disease?

Parkinson's and Alzheimer's research.

Freakonomics Radio
671. Why Has There Been So Little Progress on Alzheimer’s Disease?

So when he was hired to be the head of the neuroscience division at NIA, it made him a logical choice.

Freakonomics Radio
671. Why Has There Been So Little Progress on Alzheimer’s Disease?

Someone who had respect, had context, had prestige, had himself demonstrated a propensity for influential research.

Freakonomics Radio
671. Why Has There Been So Little Progress on Alzheimer’s Disease?

And he operated his own lab within NIA as well as directing their programs.

Freakonomics Radio
671. Why Has There Been So Little Progress on Alzheimer’s Disease?

No, there were no suspicions of him, according to the NIH.

Freakonomics Radio
671. Why Has There Been So Little Progress on Alzheimer’s Disease?

So with the cooperation and assistance of four leading forensic image experts, and that included Matt Schrag, a woman by the name of Mu Yang, who is at Columbia University, who's becoming a pretty well-known

Freakonomics Radio
671. Why Has There Been So Little Progress on Alzheimer’s Disease?

forensic image expert.

Freakonomics Radio
671. Why Has There Been So Little Progress on Alzheimer’s Disease?

Also, Kevin Patrick, who is not a scientist, but is an independent researcher who is excellent and very seasoned at looking at these images.

Freakonomics Radio
671. Why Has There Been So Little Progress on Alzheimer’s Disease?

And Elizabeth Bick, who is a world-renowned expert in scientific image analysis.