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Matthew Schrag

👤 Speaker
148 total appearances

Appearances Over Time

Podcast Appearances

Freakonomics Radio
671. Why Has There Been So Little Progress on Alzheimer’s Disease?

I found over many years of experience doing these sorts of articles that people who don't have a great story to tell often are unwilling or unable by their institutions restricting them from saying anything to a reporter.

Freakonomics Radio
671. Why Has There Been So Little Progress on Alzheimer’s Disease?

Ash, I did have a dialogue with, and she very interestingly replied that she wanted to talk with me, but her university advised her not to, and she decided that she would go along with their advice.

Freakonomics Radio
671. Why Has There Been So Little Progress on Alzheimer’s Disease?

I explained to her at the time that I thought it was terrible advice.

Freakonomics Radio
671. Why Has There Been So Little Progress on Alzheimer’s Disease?

because this was her opportunity to get her perspective into the most read, deepest look at the subject.

Freakonomics Radio
671. Why Has There Been So Little Progress on Alzheimer’s Disease?

In this case, what happens is the National Institutes of Health, which is the funder of this work, take a look at it.

Freakonomics Radio
671. Why Has There Been So Little Progress on Alzheimer’s Disease?

They agreed that there was a possible problem there.

Freakonomics Radio
671. Why Has There Been So Little Progress on Alzheimer’s Disease?

They referred it to an obscure government agency called the Office of Research Integrity at the Health and Human Services Department.

Freakonomics Radio
671. Why Has There Been So Little Progress on Alzheimer’s Disease?

This is a tiny little group.

Freakonomics Radio
671. Why Has There Been So Little Progress on Alzheimer’s Disease?

They don't have the

Freakonomics Radio
671. Why Has There Been So Little Progress on Alzheimer’s Disease?

manpower to examine every possible example of fraud or misconduct in the scientific world.

Freakonomics Radio
671. Why Has There Been So Little Progress on Alzheimer’s Disease?

And so what they do is they give it back to the university where the alleged misconduct took place, in this case, the University of Minnesota.

Freakonomics Radio
671. Why Has There Been So Little Progress on Alzheimer’s Disease?

To me, this is exactly the wrong approach because you're entrusting the organization that has the most to lose and the least to gain from a robust, complete, and publicly accessible examination of possible misconduct to do that examination.

Freakonomics Radio
671. Why Has There Been So Little Progress on Alzheimer’s Disease?

So they took years to assess Lesney.

Freakonomics Radio
671. Why Has There Been So Little Progress on Alzheimer’s Disease?

In the meantime, he was still collecting many hundreds of thousands of dollars in federal funds to continue the same lines of research that had already been proved questionable.

Freakonomics Radio
671. Why Has There Been So Little Progress on Alzheimer’s Disease?

And, I might add, published a paper after my initial story came out that we found had apparently manipulated scientific images in it.

Freakonomics Radio
671. Why Has There Been So Little Progress on Alzheimer’s Disease?

This goes on and on, and the university is going about their business.

Freakonomics Radio
671. Why Has There Been So Little Progress on Alzheimer’s Disease?

Finally, in 2025...

Freakonomics Radio
671. Why Has There Been So Little Progress on Alzheimer’s Disease?

Lesney retires from his job.

Freakonomics Radio
671. Why Has There Been So Little Progress on Alzheimer’s Disease?

He resigns from his post as a tenured full professor.

Freakonomics Radio
671. Why Has There Been So Little Progress on Alzheimer’s Disease?

This is a pretty young guy.