Michael Le Page

speaker

580 appearances 7 recordings 1 series first heard Jun 2026 last heard 5d ago

Michael Le Page’s voice in public audio — every appearance, attributed to the second.

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recordings per month · last 12 months

Recordings per month over the last 12 months — 7 in all, peaking in Jul 2026 with 4.

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The World, the Universe and Us · If We Can Make Genetically Engineered Designer Babies - Should We? · 15 Jun 2026 podcast

It should never have been tried.

That's right.

So instead of cutting the DNA, these are these are modified forms of the CRISPR enzyme.

They they sort of chemically alter one of the DNA letters and then at the same time they make a little cut, a single cut in the opposite strand of DNA.

And then when repair come repair enzymes come around, they go, they see that altered form of DNA, think, oh that's a mistake, and they correct it and they change the DNA.

DNA letter in the process.

Yeah.

And so because you're not you never cut in completely through the DNA, this is much safer, it's much rarer for things to go wrong.

And so that precision means it's a lot safer.

Yeah, this is quite complicated.

So I try and explain it simply.

So most forms of leukemia are caused by cells called B cells, those antibody-making cells.

They start dividing out of control.

And so one way of treating that, you can take another kind of immune cell called a T cell, and you can program that to go off and destroy those B cells.

And that's known as CART therapy, and it it can work extremely well in some cases.

Now, this there was a girl called Alyssa, and now what she had was a form of leukemia caused by T cells.

So if you modify T cells to destroy T cells, they're just gonna kill each other.

Yeah.

So they couldn't use a standard therapy.

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