Michael Le Page

speaker

580 appearances 7 recordings 1 series first heard Jun 2026 last heard 5d ago

Michael Le Page’s voice in public audio — every appearance, attributed to the second.

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recordings per month · last 12 months

Recordings per month over the last 12 months — 7 in all, peaking in Jul 2026 with 4.

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The World, the Universe and Us · If We Can Make Genetically Engineered Designer Babies - Should We? · 15 Jun 2026 podcast

So what they did is they used base editing to change the T cells that they were using to kill the B cells.

They changed those T cells so they didn't recognize each other as T cells and they didn't destroy each other.

Do that.

Lissa was treated in twenty twenty two and I interviewed her just a few weeks ago, in fact, and she's doing she's doing really well, no signs of recurrence.

Well, th that's been that's now been done in the US.

This team uh that haven't created children to be clear, they've just tested it on uh human embryos that were donated by parents uh were donated by couples, I should say, having IVF.

Uh they've just tested it on those embryos to see how well it works.

And so they tried making two different changes.

With with one of those changes they got a few off target

Mutations, that is the letter they when they tried to change a specific letter, it sometimes changed letters to either side of that target.

So it g it went slightly off-target.

With the second change I made that had no off-target mutations.

Now, why why did it work in one case and not the other?

So but the key thing with CRISPR is you have the sort of you the protein hooks up with what's called a guide RNA, and that guides the uh

uh protein to the precise point in the genome that you want to change.

So the thing in the first case their guide RNA was was not ideal and that's why they've got some off target mutations.

So if if you can get your guide RNAs right and you don't get these off target mutations as in the second case, then this is looking very promising for avoiding those issues we had with the the children in China where there are lots of undesired changes.

They were two cell embryos.

Oh so very early on.

Very early on.

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