Michael Le Page

speaker

580 appearances 7 recordings 1 series first heard Jun 2026 last heard 5d ago

Michael Le Page’s voice in public audio — every appearance, attributed to the second.

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recordings per month · last 12 months

Recordings per month over the last 12 months — 7 in all, peaking in Jul 2026 with 4.

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The World, the Universe and Us · If We Can Make Genetically Engineered Designer Babies - Should We? · 15 Jun 2026 podcast

Very early on.

Yes.

There's another issue, uh, and that is in in these embryos they didn't always succeed in making the changes they wanted in every single cell.

So why of the two cells.

Yeah.

So why why is that a problem?

So you think about if suppose you are trying to correct a disease that someone might inherit, you edit the embryo, you

You succeed in making that change in some cells, but not in other cells.

That embryo then develops into a baby, into a person.

Some of those cells will have that correction, some of them won't now.

Depending on what disease it is, they might still go on and develop that disease, and then you'll have failed, your gene editing will have failed because you haven't got corrected it in all the cells of the embryo.

So, this issue of some cells in the embryo being different to the

Others is called mosaicism.

And it's a big problem for gene editing applications because there's no way of tailing if it's happened.

So when people have been sort of if parents have a risk of passing on a disease and you do IVF and then you can test the embryo, if that embryo has come from there's no gene editing involved, then all those cells should be the same.

Yeah.

You can take a single cell from the embryo.

you can test it and you can be sure that child or that embryo will not develop into a child with that disease.

Yeah.

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