Nicole Kupchik

speaker

2,480 appearances 16 recordings 1 series first heard Apr 2025 last heard 16 Dec

Nicole Kupchik’s voice in public audio — every appearance, attributed to the second.

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recordings per month · last 12 months

Recordings per month over the last 12 months — 5 in all, peaking in Dec 2025 with 3.

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The Sepsis Spectrum · Can sepsis turn the liver against you? · 2 Dec 2025 podcast

So we you know, there have been so many uh studies done in humans and I have I know I give presentations on this and I've got a I call it the uh research graveyard and I have tombstones of everything that's been studied and just a lot of things just haven't panned out clinically.

And so I you know, I wonder, you know, do you know are there any human studies

That are

gonna target maybe things like our Gachaban and things that we have access to.

Now, years ago, now I'm totally dating myself.

Um, we for uh uh I think it's a little over a decade, or actually about a decade and a half, we were using activated protein C.

And then as we all know, that got pulled off the market.

Um, any thoughts on that?

Well, and I and I think the the tough that's the human factor part of all of this is that like you I think you made a great point earlier is that so many humans present late.

And you know, I mean, let's be honest, you know, uh you you're most people are probably at home sick for days on end before they come to the hospital.

And, you know, and you wonder

Like what we're finding now is so many things that we do are time dependent.

Yeah.

Well, you know, going back to activated Protein C, you know, I have no interest financially or anything, you know, in activated protein C.

But I will tell you, I did see it work clinically in patients.

And what I wondered about with some of the follow up studies that were done is was the drug given to the right patient population?

You know, 'cause of the early studies, they calculated Apache scores and they were giving it to much sicker patients.

then follow up studies, the patients weren't as sick and they didn't do as well with the activated protein C.

Yeah.

Well, okay.

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