Nicole Kupchik

speaker

2,480 appearances 16 recordings 1 series first heard Apr 2025 last heard 16 Dec

Nicole Kupchik’s voice in public audio — every appearance, attributed to the second.

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recordings per month · last 12 months

Recordings per month over the last 12 months — 5 in all, peaking in Dec 2025 with 3.

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The Sepsis Spectrum · Can sepsis turn the liver against you? · 2 Dec 2025 podcast

So I honestly did not think of the liver as being a big m uh just uh playing a huge role in our m immune response.

So let's just talk a little more.

When are you seeing the liver more on overdrive?

Is it with bacterial, viral, fungal infections, or it doesn't seem really seem to matter?

And

Like I don't mean to sound dumb, but like wha what do these Kuphar cells do with the bacteria?

Now, one of the things we see in clinically in humans is we see low platelet counts, especially in our sicker septic patients.

And we often look at that as basically a marker of severity uh or even of like organ dysfunction when uh platelet counts drop.

And we know that there's phagocytosis of platelets, but

How do we make that tie?

Like why are we seeing such low platelet counts in really sick patients?

Wow.

I mean, it's just so fascinating.

So what I mean, is there a tie between low platelet count?

I know you're looking at animal models, but I'm I'm trying to kind of be the conduit back to humans.

It i is it true or is this would this statement be true that when patients drop their platelet counts in septic shock, that is a marker of the severity of their illness?

Oh fascinating.

Okay.

This is I'm this is like all mind blowing to me.

Because uh you know, again, clinically, I think we've been uh you know, I've been doing this for three decades and we've been searching for the holy grail.

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