Nicole Kupchik

speaker

2,480 appearances 16 recordings 1 series first heard Apr 2025 last heard 16 Dec

Nicole Kupchik’s voice in public audio — every appearance, attributed to the second.

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recordings per month · last 12 months

Recordings per month over the last 12 months — 5 in all, peaking in Dec 2025 with 3.

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The Sepsis Spectrum · The Nerve That Could Stop Sepsis · 25 Nov 2025 podcast

So can you give the audience a rundown of just the research that you've been doing and the focus?

Well, and you know, we know sepsis is we know it causes so many issues.

And we know inflammation is kind of the root of a lot of the issues it does cause.

So let's just I don't know, I would love to dive in on this whole idea of the the role of the vagus nerve in inflammation.

Cause I'll be honest, I'm not really up to speed on like what the literature is showing and and its role.

So let's let's just start from that perspective.

So what is the role of the vagus nerve in in sepsis and inflammation?

Okay.

Well let's let's just dive into that. 'Cause I think a lot of times we s when we see patients in septic shock, we often think of the sympathetic nervous system being on overdrive and releasing catecholamines so that, you know, the

you know, hypothetically that their organs are preserved.

But you're saying that there's actually the parasympathetic system is playing a gigantic role in inflammation.

So let's dive in.

How is this working?

And that's something very different than we've been taught.

Now, what's interesting to me is there's been some newer literature popping up about the use of beta blockers.

In sepsis okay, so is the whole idea.

than that we're just allowing for that parasympathetic system to be turned on a little more or

Well how d how where is that connection?

Well we've well we've tried that with sepsis for years and we've realized it you're right, it doesn't work.

How do we make this connection clinically to human beings? 'Cause it you I mean, we've you've been able to show in animal models that these nervous systems actually work in concert and they're not independent of each other.

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