Paul Saladino
speaker
961 appearances
2 recordings
2 series
first heard Jan 2025
last heard Mar 2025
Paul Saladino’s voice in public audio — every appearance, attributed to the second.
Trend
recordings per month · last 12 monthsNo recordings in the last 12 months.Older appearances are listed below; set an alert to hear about the next one.
Appearances
The Shawn Ryan Show · #179 Paul Saladino - The FDA Approved Poison You Eat Every Day · 5 Mar 2025
podcast
would raise LDL and that's increasing your risk of cardiovascular disease, that doesn't make sense to me either. So we end up with this whole kind of just real confusing story, right? Where we've been told, we knew 120 years ago that animal fats were great, right? People that eat animal fats, they're vibrant, their skin looks good, they're fertile, they have libido.
Then seed oils come on the scene. They're cheaper, they're shelf-stable, and they lower cholesterol. And now we're being told to fear cholesterol. And there's some sinister things in there I can also tell you about the American Heart Association. But we're being told to fear cholesterol when cholesterol is not the problem.
And there are actually some interesting studies that have been published very recently showing that people who have higher cholesterol, in some cases very high cholesterol, and that are insulin sensitive don't have increased rates of cardiovascular disease at all. They have actually lower than a regular cohort. So this study is so important, I'll just highlight it for you.
It's from Dave Feldman and Matt Budoff. It's called the Keto Study, I believe. They published the first part of the study, I think in 2024, and they took people on a ketogenic diet. Now, sometimes people on a ketogenic diet, because you're doing fat-based metabolism, see LDL go up. But generally people doing a ketogenic diet, which is low carb, are not eating seed oils.
They're not eating processed food. They're pretty insulin sensitive as a group. So they looked at a group of 80 people in this cohort who have average cholesterol, average LDL cholesterol. I think the average LDL was 273 milligrams per deciliter. So very high LDL and corresponding LDL-C. And they looked at them and they did CT coronary angiography. Matt Budoff is one of the coauthors.
He's a CT coronary angiographer. He's preeminent in his field, a very well-respected radiologist. And what they found when they compared that to a cohort from Miami who had an average LDL cholesterol of 123 was that the two groups had the same amount of plaque in their arteries.
one group has more than double the amount of cholesterol the other group has you know but they have the same amount of plaque and the group on the keto group actually was trending toward less fat, less fat in the arteries, less atherosclerosis. And so people might say, but they still had atherosclerosis. Well, yeah, you don't know what they did before, right?
So what's being said here is that these people had been on a ketogenic diet for an average of three years. They'd probably had elevated cholesterol, LDL cholesterol for three to five years, which most people cardiologists most in the lipid space would agree is enough time to see accelerated atherosclerosis when you have more of that cholesterol in your body.
And if LDL cholesterol is causing atherosclerosis, you should see more atheromas. You should see more atherosclerosis in that population, but you don't. Again, we don't know what they did before. It's not that people on ketogenic diets in the study had zero. but we don't have any idea what they were doing before. They could have had it previously. They had less.
They had less than the Miami Heart Group, which has a much lower LDL. That raises some pretty major questions. And when you look at the analysis, there was no correlation between serum cholesterol, LDL-C, not LDL, Yeah, the LDL-C. There was no correlation between LDL-C and the plaque burden in those people. Zero. Oh, shit. So if LDL is causal, how is that possible?
So we just see the whole thing starts to get really complicated and confusing, but I'll just... The framework, the context is important. It's all about insulin resistance, in my opinion. My strong belief, I should say. It's all about metabolic health. If you're metabolically healthy, you... LDL is not a problem. And you really have to be metabolically healthy.
And whether you're keto, which I'm not a huge fan of long-term for most people, or you're not keto, being metabolically healthy is what we should be focusing on. We are hyper-focused in Western medicine on LDL cholesterol because the statin industry is a multi-billion, potentially more than that, industry.
So if LDL doesn't cause atherosclerosis, there's still a place for statins in the drug supply, but maybe we wouldn't be giving them out as much as we are now. And the whole paradigm starts to shift. We need to fix insulin resistance. And that is something that again, 86 to 93% of Americans have some degree of. That's the problem. But we think we're doing a good job as doctors.
Remember, I did four years of cardiology as a PA. I gave a lot of statin prescriptions and I was proud of it at the time because I didn't know any better. So I've been in this world. We're treating the wrong thing and we're worried about the wrong things.
And the reason this is important to me is because people invariably get healthier when they eat more red meat, when they eat more animal fats, and when they decrease seed oils and their LDL goes up.
I think it's a centralized narrative from the 1950s, from Ancel Keys, this lipid hypothesis that is then fueled by potentially company data that are trying to muddy the waters and confuse people.
Yeah, I think so. I mean, this is very contentious in Western medicine, and there are many very intelligent, well-intentioned doctors that disagree with me and still strongly believe that LDL is causal in atherosclerosis. But when I look at the data, there are too many inconsistencies. There are studies like Dave Feldman's and Matt Budoff's.
There are so many examples of people with elevated LDL who do not develop atherosclerosis. And I think that it may come down to syntax and linguistics. I would agree, LDL is involved in the causal cascade. If you are insulin resistant and we lower your LDL, your risk of heart disease is unequivocally lower.
However, we didn't treat the real cause, which was your insulin resistance and your metabolic dysfunction. And I hope that we were honest with you about the side effects of the statins or whatever we use to lower your LDL and major questions come up, not necessarily with statins, but overall with LDL lowering about all cause mortality.
Just because you're decreasing someone's risk of cardiovascular disease death doesn't mean they're living longer or living better. Because sometimes you just shift it, right? We know that you can just shift the pathology from cardiovascular disease to dementia or to cancer or to some of these other issues. And so that's not the goal. That's not treating a human. That's not a healthy human.
Showing 441–460 of 961 · page 23 of 49
← Previous
Next →