Paul Saladino
speaker
961 appearances
2 recordings
2 series
first heard Jan 2025
last heard Mar 2025
Paul Saladino’s voice in public audio — every appearance, attributed to the second.
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The Shawn Ryan Show · #179 Paul Saladino - The FDA Approved Poison You Eat Every Day · 5 Mar 2025
podcast
We want humans to live long and live well, like the Hadza. We want squaring of the morbidity curve. We want humans to be vital into old age. I'm not excited about giving someone an increased rate of diabetes or dementia, myopathy, lower libido, decreased sex hormones by lowering their cholesterol with a statin. That doesn't solve the problem to me.
We have to understand what is causing the insulin resistance. And so I'll just talk about that because it kind of wraps back to seed oils. And I'm sorry this has been so technical and such a long story, but it's a big Gordian knot, all of this. So I mentioned this earlier, metabolic dysfunction, insulin resistance, this primarily happens at the level of the mitochondria.
If you cannot take substrate from food, which is glucose or fatty acids, and process them into NIDH and FADH2, and move those electrons through the electron transport chain to make ATP, you are going to become insulin resistant. So how does that get broken? It gets broken in two major ways. The first of these is seed oils, and the second of those is sugar. And I'll talk about sugar in a minute.
Next. Seed oils, I think, are a problem at the level of the mitochondria because that linoleic acid is the most common, most abundant polyunsaturated fat that we consume today as westernized Americans. And that linoleic acid accumulates in the membranes of the mitochondria.
And there's evidence from animal models and cell culture that when you have excess linoleic acid from seed oils in the mitochondrial membrane, you get proton leak. And the whole point of the electron transfer chain is to create a gradient that the protons can flow down to make ATP. If you are leaking protons across down the gradient, you are making less ATP.
At the cellular membrane, we also know that excess linoleic acid, excess polyunsaturated fats creates leak and problems or overactivation of the sodium potassium ATPase. That's all very technical, but suffice it to say that my concern is that when you stuff yourself full of seed oils, you are creating an ATP leak in your body. You are not producing energy as well.
And that leads to metabolic dysfunction. And that is actually the root molecular cause. What's the solution? Stop eating so much linoleic acid. Return to a historically accurate, a historically consistent amount of fat. We're doing these... historically inappropriate things, right? We're doing historically inappropriate lights, we're doing historically inappropriate types of fat.
Humans are meant to be eating a mix of saturated fat and monounsaturated fat with a little bit of polyunsaturated fats. We have far too much polyunsaturated fat today, and I think that's driving, at a molecular level, the mitochondrial dysfunction that is underlying insulin resistance and metabolic dysfunction. So the solution is simple. Return to what you've always been doing.
Remember that seed oils also increase the propensity of LDL to oxidize when it gets in that arterial wall. So in so many ways,
historically horrible industrial processed oil full of hexane, benzene derivatives, oxidized oils, antimony from the plastic it's being stored in that humans have never been exposed to, which is being sold to you as safe and healthy by Harvard and Mayo because it lowers your cholesterol based on a faulty paradigm of atherosclerosis is a major, major driver of illness in humans today.
So that's the seed oil story. I'm sorry that was so long. Wow.
Yeah, so the second thing is sugar. Sugar drives metabolic dysfunction also, but not in the way that we think it does. So this is another interesting story. Sucrose is a disaccharide of glucose and fructose. Glucose and fructose are monosaccharides. Sucrose is a disaccharide. Starches are polymers of glucose. When you have a fruit, an apple, I gave you guys strawberries downstairs, right?
That has glucose and fructose in it. It has sucrose and it has both of those sugars. If I give you a strawberry, that doesn't cause insulin resistance in humans. That's pretty clear, both at an associational or an interventional level.
If I give you pure sugar, which is pure sucrose that's been refined out of that strawberry or from sugar cane or from beets, or I give you high fructose corn syrup, which is another industrial byproduct from corn, or they take corn, which only has glucose and they isomerize it and they combine it to make a high fructose corn syrup, which is essentially like a fake sugar.
If I give you either of those things, it does induce insulin resistance in humans. It's not because it raises your blood sugar. It's because it affects your gut microbiome negatively. So historically, humans would never have consumed sugar without all of the other compounds in that strawberry. So that strawberry is a complex food. It's not just sugar. It's red. It tastes, right?
There are thousands of components in that strawberry, hundreds of different chemicals in that strawberry that your body is used to getting with that sugar. And whether it's strawberry or banana or orange or honey, any of these sugar-containing foods that humans have historically consumed These compounds prevent the overgrowth of bacteria in our gut.
But if you give a human pure sugar, you get dysbiosis. That is a strict, fast pathway to dysbiosis. If you want to mess up the gut flora, give a human sugar. It doesn't matter if it's high fructose corn syrup or pure sucrose. It doesn't look like it's good for humans. But if you give a human a banana, it's fine.
Or even like orange juice, it doesn't even have to have fiber because orange juice has these same chemicals. There are naturally occurring chemicals in fruit, in honey, that mitigate the negative effects of sugar in our body. So sugar causes insulin resistance, but not because of why we think it does. We think sugar causes insulin resistance because it raises your blood sugar.
That's not why it happens. There are plenty of cultures all over the world that have 95% of their calories as carbohydrates. They don't get diabetes. So insulin-induced insulin resistance is not the pathology of carbohydrate. That's not why carbohydrates are bad. Carbohydrates are not bad as a class.
It's processing of carbohydrates that strips chemicals that naturally occur with these that our body has always expected that actually prevent overgrowth of bacteria in the gut. And there's plenty of studies that show that if you give a human or you give a mouse pure glucose, pure fructose, or pure sugar, you will get something called endotoxemia, metabolic endotoxemia. Endotoxin is a word.
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