Prof Felice Jacka
speaker
100 appearances
2 recordings
1 series
first heard Mar 2015
last heard 7 Aug
Prof Felice Jacka’s voice in public audio — every appearance, attributed to the second.
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They followed them over 12 months.
And what they found was that those who'd been receiving the fish oil were far less likely to transition to a full-blown psychotic disorder.
That's right.
So my particular interest is in prevention, but I'm also, as I mentioned before, running the first randomised control trial to look at whether if you take people who have depression and you help them to improve their diet, does that result in an improvement in their mood symptoms?
So what...
There's a number of fields, particularly in neuroscience and the work that are done in animal models, that tell us about the impact of refined carbohydrates and high-fat diets on many different aspects of the brain.
Brain plasticity, gene expression, particularly if you're talking about early life exposures.
And of course, diet has a really quite profound effect on immune functioning.
And we're starting to understand that depression may, for some people, be actually an immune disorder.
Well, certainly in schizophrenia you see increases in this immune response and oxidative stress, as you do in all of the psychiatric disorders.
There's certainly an emerging discussion around early life immune dysfunction and even maternal immune dysfunction.
as a risk factor for schizophrenia.
And our increasing focus is now on the gut microbiota and the role that that plays in both mental and neurodevelopmental disorders and mood and behaviour.
Profoundly.
So the things that impact on gut microbiota are really diet, medication use and stress, and short- and long-term diet certainly have a very rapid impact on the gut microbiota.
Well, that's right.
And it's not just your heart.
You know, so many of the non-communicable disorders like heart disease and diabetes and obesity, metabolic syndrome,
They very commonly co-occur with depression.
And we're now starting to understand that the fundamental underlying pathology that influences the risk for heart disease, metabolic syndrome, et cetera, may also be the same for depression.
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