Professor Luke O'Neill

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1,535 appearances 7 recordings 2 series first heard Apr 2026 last heard 3 Sep

Professor Luke O'Neill’s voice in public audio — every appearance, attributed to the second.

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Recordings per month over the last 12 months — 7 in all, peaking in May 2026 with 3.

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Show Me the Science with Luke O'Neill · The Science of Gut Health · 21 May 2026 podcast

So could you take a probiotic

in a yogurt drink with a particular bacteria and then give the immunotherapy, the checkpoint blockers.

They're called checkpoint blockers because the immune system often has these checkpoints that stop it working.

And tumors are very good at bringing down the checkpoint.

If you block the checkpoint, the immune system rushes in to kill the tumor.

And it turns out that certain bacteria are boosting the effect of the checkpoint blockers, if you can follow that.

So now they're doing trials.

If you take a certain bacteria with a checkpoint blocker, would it increase the response?

And maybe we'll go from a 20% response to a 40% response.

You never know.

Very exciting part of research.

Now, the last thing to mention on this, which I'll spend a little bit of time on because it's interesting, and it gets a bit nasty.

Get ready.

You're going to go, oh, that sounds terrible.

Fecal transplant, right?

Now, what this is, is can you take the stool, we'll call it that, from someone and then make a drink out of it and give it to someone else?

Now, the Chinese have been doing this for hundreds of years, it turns out.

It's called a fecal microbiota transplant or FMT.

And that fecal microbiota will have the right composition to help you respond to certain things.

Now, what are they doing here?

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