Professor Luke O'Neill
speaker
1,535 appearances
7 recordings
2 series
first heard Apr 2026
last heard 3 Sep
Professor Luke O'Neill’s voice in public audio — every appearance, attributed to the second.
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recordings per month · last 12 monthsRecordings per month over the last 12 months — 7 in all, peaking in May 2026 with 3.
Appearances
This sounds most unusual.
They're finding people with cancer who do respond to these immunotherapy approaches, right?
And then they figure out the certain bacteria in that person's gut that's increasing their responsiveness.
And they're making a tablet out of that fecal material from that person who's responsive, giving it to someone else, and then testing the immunotherapy.
In other words, you're identifying responders and they're responding partly because of the right bugs in their gut and you're transferring those bugs to someone else to increase their responsiveness.
Doesn't that sound rather peculiar?
But as I say, this big thing in nature medicine that just came out, three papers back to back.
There were two papers on kidney cancer and one on lung.
And they gave the people fecal material from responders.
And guess what?
First of all, it was safe.
Very importantly, it was a safety trial, really.
And there was indications.
that doing that would increase the response to these checkpoint inhibitors.
So we may see this emerging as an adjunct to immunotherapy or indeed to chemotherapy.
Now, using faecal material does sound unpleasant, but they can do it.
They can clean it up a bit and stick it in a tablet and you can just take it.
Sounds unusual, but it is possible to do.
And that'll be one way to do it.
But it's very hard to control that and
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