Sei Lee
speaker
547 appearances
9 recordings
1 series
first heard Feb 2017
last heard Oct 2022
Sei Lee’s voice in public audio — every appearance, attributed to the second.
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Appearances
I don't know what we were able to do was to look at trials that were starting these medications.
And so I can tell you with a high degree of confidence that this is how long after you start this medicine that we can see this magnitude of benefit.
The question you're asking is, if somebody's been on it for a long time and we stop it, is the time for the harms, for the fracture risk to go back up, is that the same as the time that it takes when we start it for the fracture risk to go down?
And I would say that...
It's unclear.
I think going out on a limb, I would say compared to other drugs, this drug, especially from what we know about the mechanism of action, that the bisphosphonates actually get deposited into bone.
the stuff that I remember learning about these drugs is that they actually seem to have a long tail of kind of being remaining in the body.
So the correct answer is we don't know the, but if we need to make a decision, I would say that my sense is that the,
If we take it off, my sense is that it will probably remain having an effect for substantially longer than the 12.4 months that we found for kind of the time to benefit.
Yeah, so I think one of the things that I've always been thinking about is how we could use time to benefit as a way of prioritizing different preventive interventions in older adults.
Because obviously, if something is going to help you in one year,
whereas something else is going to help you in 10 years.
It doesn't seem like too much of a stretch to say, I think we should focus on the thing that's going to help you in one year.
And so one of the things that we looked at was trying to combine these concepts of
life expectancy with the time to benefit for a variety of different interventions.
And so we've been working on this new page for e-prognosis where we try to put all those things together.
And Dr. Smith magically made it appear.
It's amazing.
Yeah, so basically what you have on the, you have rows of different type of interventions, like we have intensive blood pressure control, statins for primary prevention, and then on the, that's the different rows.
And then across the x-axis is the number of years.
Showing 181–200 of 547 · page 10 of 28
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