Sei Lee
speaker
547 appearances
9 recordings
1 series
first heard Feb 2017
last heard Oct 2022
Sei Lee’s voice in public audio — every appearance, attributed to the second.
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The other thing that I would say is because there is no
single right answer for all patients, one of the things that we do is actually identify the time to benefit for several different clinically meaningful benefit thresholds.
So we talk about if you believe avoiding one fracture for 100 women treated is a clinically meaningful benefit, this is the time to benefit for one in 100.
If you believe avoiding one fracture in one in 500 women is a clinically meaningful benefit, this is the time to benefit for that absolute risk reduction threshold.
So we provide a range of these clinically meaningful benefits.
And depending on, I think, the individual patient's values and preferences, differing thresholds may be appropriate.
I want to jump in here and just say, overall, I feel like when I saw the results, I was like,
dang, bisphosphonates are really good.
They work pretty fast.
And my kind of takeaway from the results was like, yeah, almost every older adult should be on bisphosphonates.
We should try to figure out a way to get them on because not only do they work, which we knew from previous studies, from the RCTs themselves and previous systematic reviews and meta-analyses,
Our time to benefit analysis shows that they work pretty fast.
12.4 months is not very long.
And so I would say, you know, my takeaway from this was like, good drugs work good and fast.
Yes.
Yes.
Thank you.
Thank you for that clarification, Alex.
Oh, I get all the easy questions, right?
The problem is that I would say it is, I think the fairest answer is it's unclear.
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