Sei Lee
speaker
547 appearances
9 recordings
1 series
first heard Feb 2017
last heard Oct 2022
Sei Lee’s voice in public audio — every appearance, attributed to the second.
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Appearances
However, the flip side is the harms are real and the burdens are real.
I remember my mother, she complained bitterly about like,
How she hated her gums always bleeding and how easily she bruised.
So it's just, I think it's a substantial burden on the quality of life, but it's also, I think, clearly beneficial in terms of avoiding this terrible alcohol stroke.
Boney M. Yeah.
Rah Rah Rasputin.
I was going to say, you know, one thing is like the reason why we don't have good data on discontinuation is because RCTs are expensive.
Therefore, the only people doing RCTs are the most commonly it's done by drug companies because there's a profit motive of if we show benefit, then we can sell lots of this medication.
What we really need are discontinuation trials, where if we stop this, is it going to cause harm?
But the problem is there is no financial incentive, except for CMS and from a societal perspective, on doing any of these discontinuation trials.
It takes millions of dollars, tens of millions, sometimes hundreds, at least tens of millions of dollars to run these trials.
And there is nobody who is willing to put up that sort of money to see if we should use less of any of these drugs.
So I think that is a fundamental problem and where, unfortunately, I think the NIH, even though it has a big budget, just doesn't have enough to be able to do these discontinuation trials for all.
all the different medications for whom that information would be really helpful.
And that's somewhere
Yeah, I mean I think the way that I think about this is just going back to most of the patients that I see have multiple diseases and about like 50 things that are recommended for them.
And I look at this as a way of thinking about how do I prioritize what's most important?
Because clearly the answer can't be that they should be on 50 different medicines.
The answer has to be
That we should focus on the things that are most important.
Showing 221–240 of 547 · page 12 of 28
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