Time to Benefit of Statins for Primary Prevention: A Podcast with Lindsey Yourman and Sei Lee
episode
GeriPal - A Geriatrics and Palliative Medicine Podcast
44 min
5 speakers
8 chapters
transcribed 3 days ago
Transcript
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Transcript generated automatically by AI and may contain errors.
What is lag time to benefit and why does it matter for statin therapy in older adults?
The JerryPowl Podcast is brought to you by Archstone Foundation, preparing society and meeting the needs of an aging population. And now, here are your hosts.
Welcome to the JerryPell Podcast. This is Eric Quadera. This is Alex Smith. And Alex, most people won't even recognize this, but just in case want to rem tell all of our listeners that we're switching uh podcast hosts. So we're going to Libson. So if you're having any difficulty getting a hold of us through your favorite podcast apps, just shoot us an email and let us know because we can try to look into why our podcast isn't reviewing. Refreshing there. And again, we always appreciate any reviews or likes on your favorite podcasting app, including iTunes. So if you have a moment, please do that. And with that, Alex, should we talk about who's with us today?
Yes, we have some special guests with us. We have Lindsay Yorman, who is well known to us, graduate of UCSF, took a year off, did some research with me, is been working with say, is one of the founding members of ePrognosis. Uh Lindsay is currently an assistant professor and director of geriatrics quality improvement at the University of California, San Diego. Welcome to the JerryPal podcast, Lindsay.
I'm excited to be here.
So good to have you on. And we have returning to the Jerry Pell Podcast, Say Lee, who's professor of medicine at UCSF in the division of geriatrics, and has been a guest and a host frequently on the Jerry Pell Podcast. Welcome back, Say.
Hello. So we're gonna be talking about the concept of lag time to benefit, including your most recent article. Um published it with Jamma IM or Jamma IM. But before we do that. We always ask for a song request. Lindsay, do you have a song request for Alex?
Yes, imagine by John Lennon.
And why imagine?
Well, I knew we'd be doing this during election week. And I wanted to pick a song that had a a relatively tranquilizing effect.
Election
month. Yeah, the time of this podcast, everybody, the election is not officially over yet. So we still don't know the result. You'll when you listen to it, hopefully it will be
Hopefully. We hope so.
But um just uh and it it has a theme of unity and compassion that I think is really important right now.
It's great. And I've recruited Kai Smith, my son here. Giveaway of Kai. Kai is uh in ninth grade and he's plays guitar and he's appeared previously on this podcast, so he's gonna do the guitar part uh for Imagine here. Here we go.
Imagine there's no heaven. It's easy if you try. Well that Only sky. Imagine all the people. Living for today you You may say I'm a dreamer Uh But I'm not the only one. Uh Some day you'll join us. And the world will be as one.
That was fantastic. Not to downplay your guitar skills, Alex, but Kai, that that was pretty amazing.
Yeah. That was beautiful on all accounts.
Thank you.
All right, Kai's gotta go back to class. But uh yeah, on the podcast version he'll join me at the end.
Okay. Lindsay, I'm gonna start off with you. We're gonna be talking about like lag time to benefit. Maybe maybe even before I asked the question about kind of how did you get interested in the subject, can you just give us like a you or say brief definition of what what lag time to benefit is?
Sure. Uh lag time to benefit is it answers the question of when you will benefit from something.
How did the researchers define and measure the time to benefit for statins in the JAMA IM meta‑analysis?
So we often in research studies look at how much will I benefit or how much will it help, but we less often look at when will I benefit or when will I help? So a definition would be the time between when Usually a preventive intervention is started to the time when a an improved health outcome is seen.
How did you get interested in this as a subject?
I got interested in this because of my interest in prognostication. In other words, predicting how long somebody will live or how well someone will do in their disease course. And my interest in prognostication was really about decision making. You know, when should we give tests and interventions, especially to seriously ill or frail? Older adults. And and one of those things is thinking about well, how long will this is this person likely to live?
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Chapters
8 chapters
1
What is lag time to benefit and why does it matter for statin therapy in older adults?
0:01–4:31
2
How did the researchers define and measure the time to benefit for statins in the JAMA IM meta‑analysis?
4:31–10:06
3
Which cardiovascular outcomes were examined and what were the findings on the timing of benefit?
10:06–16:11
4
What are common examples of preventive interventions with short versus long lag times to benefit?
16:11–21:50
5
What are the main harms of statins and how do they compare to the expected benefits?
21:50–27:09
6
How does patient age, frailty, and life expectancy influence the decision to start a statin?
27:09–33:21
7
What are the clinical and policy implications of a 2.5‑year time to benefit for primary prevention?
33:21–39:23
8
How should clinicians communicate the time‑to‑benefit and number‑needed‑to‑treat to patients considering statins?
39:23–45:02
Speakers
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