Sharon Brangman
speaker
219 appearances
2 recordings
1 series
first heard Jan 2023
last heard Aug 2023
Sharon Brangman’s voice in public audio — every appearance, attributed to the second.
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Appearances
And then they go out and try to recruit somebody to test their hypothesis when they don't even know any other perspective.
So you end up with a very narrow perspective.
And what we all want to do as physicians and scientists is have a broad perspective about what we're doing.
So that's a very good point because the clinical trials that we run at Upstate are mostly for people who have mild cognitive impairment or mild Alzheimer's disease.
And when I go out and do outreach, I find people who are already moderate.
They didn't get to a doctor or their doctor didn't pay attention to them and told them, oh, don't worry about it.
Or they never had good treatment for their hypertension for so many years or their diabetes.
So they were much, much more advanced at a younger age.
So we have to look at those social determinants of health and how they impact somebody and the care they get and the research questions we ask.
Well, if you look at Gantanirab, for example, which was shown not to have any benefit, and it was done in a trial that didn't have very much diversity, what if that drug turned out to be
huge impact in African-Americans.
We will never know now because that drug is not going to move forward.
And I'm not even sure we understand amyloid deposition in anyone other than primarily white men.
Is there going to be differences in amyloid in older people versus younger, old versus women versus men?
Who knows?
even more complicated,
like we know in which is so prominent in African-Americans can impact your amyloid deposition.
Who knows?
We just haven't looked at it.
I think we should do our best to get as many people in from various groups as we can.
Showing 181–200 of 219 · page 10 of 11
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