Sharon Lewin
speaker
233 appearances
3 recordings
1 series
first heard Oct 2007
last heard Feb 2020
Sharon Lewin’s voice in public audio — every appearance, attributed to the second.
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Appearances
That's exactly right.
So people initially thought that if you were on treatment long enough, you just wait till those infected cells die off and then perhaps you could be on treatment for ten years and that may be long enough for those infected cells to die off.
But once we develop ways of measuring those latently infected cells, the calculations now are you'd need to be on treatment for sixty years, so effectively lifelong treatment, unless we develop ways to target those latently infected cells.
Exactly, 'cause that's when the drugs can work.
The drugs work on the enzymes or bits of the virus that help it replicate, and that's how the drugs work.
The drugs currently don't work on those bits of virus stuck into the host DNA.
It would be fantastic to do something before it integrates.
And in fact there are a new class of drugs called integraze inhibitors which block integration.
Yeah, exactly.
They're new, they work very well, they'll probably become widely used but currently we only use them in people with difficult to treat HIV.
The problem is that even if we diagnose HIV within a week or two of becoming infected, you've already got this whole pool of latently infected cells that's set up within weeks of infection.
So you can't get rid of those infected cells even if you then went on an integrase inhibitor.
So what we've been doing is trying to mimic what happens in the tissue or in a person's body to allow infection of resting cells.
And we focused on a particular protein or something called a chemokine.
Which is a protein that directs cells around the body.
It's like a chemical messenger.
It it sends out a message.
The cell that it's talking to has a target and for us that target is C C R seven.
then the
That's right.
Showing 181–200 of 233 · page 10 of 12
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