Sydney Lupkin
speaker
1,064 appearances
108 recordings
3 series
first heard Dec 2024
last heard 3d ago
Sydney Lupkin’s voice in public audio — every appearance, attributed to the second.
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recordings per month · last 12 monthsRecordings per month over the last 12 months — 93 in all, peaking in Jul 2026 with 21.
Appearances
Patient taking more than 300 milligrams responded to the treatment.
Every patient?
It was unheard of, Emily.
And because it was 1999, it was also the early days of blogging and internet chat rooms.
So the patients were talking to each other.
They knew that they had to scale up trials and get the drug application to regulators and like fast.
And that's where the folks at Novartis come in.
That's the drug company, right?
Right.
So the next step would be for a drug company to take the drug to the FDA for approval.
To do that, you've got to look at the data and prepare a whole package.
Entered in Sagothman, who was right out of school and got hired as a biostatistician.
She became the statistical lead on the project, working long hours.
What was she doing?
So one of her jobs was to look at survival curves.
Yeah.
So Gleevec was able to switch the enzyme to the off position, shutting down that cell overgrowth, which let patients' white blood cell counts return to normal.
This is so inspiring.
And when Gleevec was approved on May 10, 2001, it was the fastest approval at the time, 72 days.
And everyone from the NIH to the FDA to the HHS secretary to the company executives wanted to take a bow.
Showing 521–540 of 1,064 · page 27 of 54
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