Can “blood filtration” act like an oil change for chronic inflammation? In this episode, Dr. Mobeen Syed, also known as Dr. Been, returns to discuss a hot topic in chronic inflammation and spike-related syndromes: therapeutic plasma exchange (TPE) and other blood filtration approaches. We break down what these procedures actually do, what they can remove from circulation, and why that might matter for brain fog, fatigue, microvascular dysfunction, and neuroinflammation.Dr. Been outlines the core methods: classic plasma exchange, immunoadsorption, and other extracorporeal options. We discuss the proposed “reset” effect, including reducing inflammatory mediators, autoantibodies, and abnormal clotting signals that may keep the body stuck in a vicious cycle.We review a sham-controlled randomized trial that found TPE to be safe but ineffective in that cohort, and discuss why a single intervention may help only a subset, if at all.If you want a clear, mechanism-first explanation without the hype, this conversation is for you. Share it with someone experiencing brain fog or fatigue, and subscribe for more evidence-based brain health deep dives.“Normally, the body is very efficient in removing extraneous harmful substances. When the body is unable to remove them because they are difficult to remove (like beta-pleated fiber sheets) and they are being produced a lot, we need to give the body a break. So we clean out the plasma.” ~ Dr. Mobeen Syed, MD, MScIn this Episode00:00 - Introduction to Dr. Mobeen Syed, MD, MSc03:16 - Dr. Been's opinion on the benefits of TPE05:02 - Can we remove bad things from the blood?11:44 - The core idea: dislodge first, filter after24:04 - What the studies say about TPE49:41 - Can TPE reverse the effects of chronic inflammation and spike protein?53:58 - Clarification of concepts and terminologies discussed1:02:17 - Key takeaway from today's episodeResources:- Top Supplements for Alzheimer's Guide - https://bit.ly/drjoshguide- Therapeutic Plasma Exchange: Current and Emerging Applications to Mitigate Cellular Signaling in Disease - https://www.mdpi.com/2218-273X/15/7/1000- Persistent clotting protein pathology in Long COVID/Post-Acute Sequelae of COVID-19 (PASC) is accompanied by increased levels of antiplasmin - https://pmc.ncbi.nlm.nih.gov/articles/PMC8381139/- Functional autoantibodies against G-protein coupled receptors in patients with persistent Long-COVID-19 symptoms - https://pubmed.ncbi.nlm.nih.gov/33880442/Connect with Dr. Mobeen Syed, MD, MSc: - Website - https://members.drbeen.com/courses- YouTube - https://www.youtube.com/@DrBeenMedicalLecturesConnect with Dr. Josh Helman, MD:- Instagram -

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