In this episode, Dr. Jihane N. Benhammou of UCLA discusses the recently published article titled "Lipophilic statins inhibit YAP coactivator transcriptional activity in HCC cells through Rho-mediated modulation of actin cytoskeleton." NEW & NOTEWORTHY Statins are widely used for the treatment of cardiovascular diseases. Recently, their use has been associated with a decrease in the incidence of hepatocellular carcinoma (HCC); however, their mechanism(s) has remained elusive. In this study, we delineate the mechanism by which statins affect the Yes-associated protein (YAP), which has emerged as a key oncogenic pathway in HCC. We investigate each step of the mevalonate pathway and demonstrate that statins regulate YAP via Rho GTPases. Article Citation: Lipophilic statins inhibit YAP coactivator transcriptional activity in HCC cells through Rho-mediated modulation of actin cytoskeleton Jihane N. Benhammou, Bo Qiao, Arthur Ko, James Sinnett-Smith, Joseph R. Pisegna, and Enrique Rozengurt American Journal of Physiology-Gastrointestinal and Liver Physiology 2023 325:3, G239-G250

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