In this podcast Steven Hutchens and Dr. Somshuvra Mukhopadhyay of the University of Texas at Austin discuss the recently published research titled "Hepatic and intestinal manganese excretion are both required to regulate brain manganese during elevated manganese exposure." NEW & NOTEWORTHY This article shows that, in contrast with expectations from prior studies and physiological conditions, excretion of manganese by the intestines and liver is equally important in controlling brain manganese during human-relevant manganese exposure. The results provide foundational insights about the interorgan mechanisms that control brain manganese homeostasis at the organism level and have important implications for the development of therapeutics to treat manganese-induced neurological disease. Article Citation: Hepatic and intestinal manganese excretion are both required to regulate brain manganese during elevated manganese exposure Steven Hutchens, Thomas P. Jursa, Ashvini Melkote, Stephanie M. Grant, Donald R. Smith, and Somshuvra Mukhopadhyay American Journal of Physiology-Gastrointestinal and Liver Physiology 2023 325:3, G251-G264

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