In this insightful episode of the Chain Reaction Podcast, Michael Ostroumov welcomes Stephen Holcomb, Director of Logistics at Refeyn, to explore the dynamic contrasts between logistics in multinational corporations and startup environments. With a career rooted in a passion for structure and problem-solving, Stephen shares his journey from GSK and Halion to Refeyn, shedding light on the nuances of cold chain logistics, supplier collaboration, and scaling operations in life sciences.Listeners gain a behind-the-scenes look at how Stephen manages temperature-sensitive shipments, builds trust with logistics partners, and tackles the complexity of regulatory requirements in global supply chains. His reflections on transitioning from tribal knowledge to data-driven SOPs offer a practical framework for scaling operations while maintaining quality and compliance.Guest BioStephen Holcomb is the Director of Logistics at Refeyn, a biotechnology company specializing in mass photometry. With deep expertise in supply chain and cold chain logistics, Stephen has led operations across global pharmaceutical giants like GSK and smaller, high-growth life science companies. He combines strategic thinking with a hands-on approach, ensuring logistics excellence across packaging, warehousing, and regulatory navigation. His passion for structured problem-solving and data-driven decisions has positioned him as a trusted leader in operational scaling and logistics innovation.TakeawaysCold chain logistics in life sciences require contingency planning due to customs delays and product sensitivity.Startups benefit from flexible operations, but require strong documentation to scale.“Tribal knowledge” is a bottleneck at scale-document early, even imperfectly.Choosing partners with a “teacher’s heart” fosters mutual growth and better results.Active vs. passive cold chain strategies need balancing between sustainability and reliability.Splitting ambient and cold shipments mitigates customs risks and improves delivery rates.Building data infrastructure early supports effective scaling and future AI adoption.Trust in suppliers must be earned through transparency-not gifts or shortcuts.Sales anecdotes must be validated with delivery KPIs to inform improvements.Logistics professionals should embed themselves in ERP systems to extract meaningful insights.Sustainable packaging needs alignment between company goals and supplier capabilities.Cultural fit with suppliers can make or break long-term partnerships.Chapters 00:00 Introduction and how Stephen got into logistics 03:00 Career journey across multinationals and startups 06:20 Unique challenges in cold chain logistics 08:55 Selecting the right partners with a teaching mindset 12:00 Cold chain technical hurdles and customs triggers 16:50 Managing ambient vs. cold shipments 19:45 Scaling operations and replacing tribal knowledge 22:00 Importance of SOPs and data collection 26:00 Using data to navigate customer concerns 29:10 Building trust and integrity with suppliers 32:00 Anecdote: When a supplier offered rum 34:00 Final reflections and takeawaysLinkedIn⁠Stephen HolcombMichael Ostroumov

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