¡Este episodio es para todos los que tenemos músculos...! Te platico por qué el músculo es considerado como un órgano metabólico y endocrino. El músculo participa en la captación de glucosa, almacena energía y libera miocinas (como la IL‑6) que comunican con hígado, tejido adiposo, hueso y tu sistema inmune. Te explico un poco sobre la relación bidireccional entre el músculo y la inmunidad, el impacto del envejecimiento y la inflamación de bajo grado. La recomendación práctica es moverse y hacer fortalecimiento regular para preservar tu masa muscular, tu fuerza y tu salud metabólica. ¡Este sí te tiene que servir! Aquí los links: DeFronzo RA, Tripathy D. Skeletal muscle insulin resistance is the primary defect in type 2 diabetes. Diabetes Care. 2009;32(Suppl 2):S157-S163 https://doi.org/10.2337/dc09-S302 Richter EA, Hargreaves M. Exercise, GLUT4, and skeletal muscle glucose uptake. Physiol Rev. 2013;93(3):993-1017 https://doi.org/10.1152/physrev.00038.2012 Pedersen BK, Febbraio MA. Muscle as an endocrine organ: focus on muscle-derived interleukin-6. Physiol Rev. 2008;88(4):1379-1406 https://doi.org/10.1152/physrev.90100.2007 Pedersen BK, Febbraio MA. Muscles, exercise and obesity: skeletal muscle as a secretory organ. Nat Rev Endocrinol. 2012;8(8):457-465 https://doi.org/10.1038/nrendo.2012.49 Albrecht E, et al. Irisin – a myth rather than an exercise-inducible myokine. Sci Rep. 2015;5:8889 https://www.nature.com/articles/srep08889 Jedrychowski MP, et al. Detection and Quantitation of Circulating Human Irisin by Tandem Mass Spectrometry. Cell Metab. 2015;22(4):734-740 https://doi.org/10.1016/j.cmet.2015.08.001 Tidball JG. Regulation of muscle growth and regeneration by the immune system. Nat Rev Immunol. 2017;17(3):165-178 https://doi.org/10.1038/nri.2016.150 Cruz-Jentoft AJ, et al. Sarcopenia: revised European consensus on definition and diagnosis (EWGSOP2). Age Ageing. 2019;48(1):16-31. https://doi.org/10.1093/ageing/afy169 Franceschi C, Campisi J. Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. J Gerontol A Biol Sci Med Sci. 2014;69(Suppl 1):S4-S9. https://doi.org/10.1093/gerona/glu057 Bull FC, et al. World Health Organization 2020 guidelines on physical activity and sedentary behaviour. Br J Sports Med. 2020;54(24):1451-1462 https://doi.org/10.1136/bjsports-2020-102955

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“What did the council decide on item 42?” — answered with the speaker and the moment.

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