'One Health' is a contemporary movement based on a long-held observation: that the health of humans, animals, and the environment are inextricably linked. In the current issue of the Internal Medicine Journal, Prof Peter Collignon FRACP has published a One Health-informed clinical perspective: Antibiotic Resistance – Are We All Doomed? But paradoxically, he says, he's optimistic about the futureOn this episode, Prof Collignon is joined in a review of his article by fellow ID physician Dr David Looke FRACP. They discuss the sobering trends in global and Australasian resistance rates, mechanisms driving the spread of resistance genes, and practical steps doctors can take for better antibiotic stewardship. This episode is presented in partnership with the Internal Medicine Journal, the official peer-reviewed publication of the College's Adult Medicine Division. Links to resources mentioned on the show are provided below. Prof Collignon's full article is available via Wiley Online Library. Editorial feedback was provided by RACP Fellows Dr Bruce Foggo, Prof David Gordon and A/Prof Matthew Links. Please visit the RACP website for a transcript embedded with citations. Fellows of the College can claim CPD credits for listening and additional reading.

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