Stop Taking Supplements Blindly: The Cell Signaling Truth | Dr. Tyler Panzner
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What is the main topic discussed in this episode?
I'm here to really help people live a better life. And it's just one of those angles, perspectives that I've seen that a lot of people miss out on because it comes down to the timing and the interactions. And that's what pharmacology is. And there's just a massive lack of pharmacology education or knowledge in the holistic space.
You are tuned into the Dr. Tina Show with Dr. Tina Moore. For more, visit drtina.com. My guest today is Dr. Tyler Pansner. He is a PhD scientist turned holistic genomic health coach. And I was absolutely fascinated by this guy. I found him on Instagram months ago and I'm just blown away with the content that he brings and the unique perspective on human health and disease. His background is both as a cell biologist and pharmacologist, and this allows him to understand how vitamins, supplements, hormones, drugs, and lifestyle changes all interplay and impact our cellular biology. We had a fascinating discussion today about the cell signaling model of disease, as he calls it, and the different signaling pathways which impact like little levers
every aspect of our health from anxiety to pain and so much more. I think you're going to find this conversation mind blowing. And I was delighted to have Dr. Pansner as my first guest of 2026. So let's jump in. Dr. Tyler Pansner, thank you so much for coming on the Dr. Tina show today here in the early January 2026. You're my first guest of the new year. So thanks for being here.
Yeah, thanks for having me on. Hopefully we could start the year off with a bang, talk about some cell signaling pathways and how I view these things as basically the strings that you can puppeteer to puppeteer your cells, tell them what to do, tell them what not to do.
I love it. One of my good friends did a talk at A4M on the cell danger response, and it was over a lot of people's heads. I followed. I understand that concept, but I think it's such an important idea that people really need to get understanding of in a way that is digestible because it doesn't... The thing I love about you and your content and when I found you on Instagram is you're always explaining supplements and you're explaining... actually why we should be hesitant in many cases. And I completely agree. As a naturopathic physician, I am not one to just throw most supplements, mamsy-pamsy at people. I'm always the one in the group chat that's like, hey, you might want to be careful with that, and here's why.
So your content is spot on, and I know it ties in with that cell danger response. So let's just kind of unwrap that for the audience.
Yeah. So, well, the cell danger response... That's a type of cell signaling, right? So let's just zoom out even more. There are, depending on how you classify it, dozens or hundreds of cell signaling pathways. So when there's a cell, let's talk about a cell in a Petri dish. How does a cell know where to go? How does it know where they go left or right? If you put two cells apart from each other, how do they know to reach out to each other and connect together? Cell signaling pathways. So how our cells reach and detect, oh, I'm grabbing type two collagen. I'm gonna remodel my extracellular matrix, which is my skeletal backbone to basically make an arm, grab and reach out and pull myself around. This can be applied to everything.
Let's take vitamin D for example. We know that low vitamin D is linked to autoimmunity, inflammation, mental health conditions, you name it, so many actual hormonal issues. So when you get vitamin D, what happens? Well, we'll skip all the mumbo jumbo of how it gets made and transported, this, that, but that vitamin D binds your DNA on a receptor. And that stimulates the cell signaling pathway of vitamin D. Now, depending the type of cell that it's talking to, if it's a brain cell, it'll tell to make more dopamine, make more serotonin. This is why seasonal depression exists. If it binds to a immune cell, it can quiet it down and shift away from a pro-inflammatory state. If it's an osteoblast or a bone cell, it stimulates the formation of bone.
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Chapters
5 chapters
1
What is the main topic discussed in this episode?
0:00–7:30
2
What is the cell signaling model of disease and why does it matter?
7:30–11:11
3
How does the cell danger response link stress, environment and chronic symptoms?
11:11–14:44
4
How does sunlight and vitamin D signaling affect mood, immunity and bone health?
14:44–1:13:07
5
Why can vitamin D blood levels be misleading and how should dosing be personalized?
1:13:07–1:17:57
Speakers
3 identifiedMore from The Dr. Tyna Show
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