Serena Williams and Oprah on Deciding to Take GLP-1 Medications

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The Oprah Podcast 1h 7m 6 speakers 8 chapters transcribed
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What is the significance of GLP-1 medications in obesity treatment?

Oprah Winfrey 0:00
But I love to dance. I can drop it. I got knees like Meghan now. Would you like to see? Yeah, yeah. I would love to see.
Unknown 0:18
OK. OK, I'll be like, hey. Hey.
Oprah Winfrey 0:21
Hi, everybody.

How does obesity relate to genetics and environment?

Oprah Winfrey 0:22
Thank you for joining me on the Oprah podcast. So great to be here with you who are watching and those of you who are listening and great to be with this fantastic audience in New York City. So I am really, really, really excited for this episode because I have been waiting to share with you all the details of how my life has just opened up in ways that I could never have imagined, okay? I feel strong, I feel vibrant, and I feel more connected and alive than I have in decades, in decades. And I can honestly say I feel liberated. I feel a sense of freedom. And the reason I'm so excited to share this is because just like me, I know that 74% of Americans, that's almost Three quarters of us in this country share the same struggle, being overweight or living with obesity.
Oprah Winfrey 1:30
And besides cancer, did you know this?

What personal experiences does Oprah share about her weight journey?

Oprah Winfrey 1:32
Besides cancer and heart disease, this is the defining health crisis of the modern age. And for the first time, there actually is real hope. So if you're one of those hundreds of millions of people, or you love somebody who who is one of the hundreds of millions of people struggling with their weight because of obesity, maybe this rings true for you. I can say that almost for as long as I can remember, weight has been a source of shame and embarrassment for me. In fact, I can remember the very first time I was embarrassed by the idea of weight.

Why did Serena Williams initially hesitate to take GLP-1s?

Oprah Winfrey 2:14
I'd gotten a scale at the Kmart and I was in the hallway standing on the scale and my father passed by and he says, no need you weighing yourself because you know, you're gonna be big. You're going to be big. And no matter what you do, you're always going to be big. He says, have you seen your mother? Have you seen your mother and your mother's sisters? And he tells the story, he says, I had your mother and your mother's sisters in the back of my Buick and I could hardly drive off with my Buick because they were so big. And I remember that moment and I carry that with me throughout my life. You're gonna be big, you're gonna be big. Remember your mother, remember your aunts. And about three years ago, that core belief that I was destined to be big
Oprah Winfrey 3:03
started to shift in the most profound way when I learned that for so many of us, obesity is a disease. The science is now clear. Obesity is not a choice. It is not caused by a lack of willpower or inherent laziness or you not doing enough. It is a disease.

What transformations did Julius Graham experience on GLP-1 medications?

Oprah Winfrey 3:26
And this is one of the most astonishing revelations of my lifetime, I have to say. So I want to introduce you to Dr. Anya Yasteroff. She is an endocrinologist and professor at the Yale School of Medicine. And hi, Anya.
Dr. Ania Jastreboff 3:41
Hi. Hi, Oprah.
Oprah Winfrey 3:42
For 15 years, Dr. Anya has been at the forefront of the research on the new GLP-1-based medications. And now she has written a book. And I tell my weight loss story in the book. And the book is called Enough. Enough.
Enough.

How do GLP-1 medications work to combat obesity?

Oprah Winfrey 4:00
Your health and weight and what it's like to be free. So my hope is that this book will help all of you who are on your own weight journey, whether you are taking the new GLP-1 medications or not. It is the book that I wish I had when I'd started and wish I'd had long ago when I didn't even know that obesity was a disease. So welcome back to the podcast, Dr. Anya. Thank you so much for having me. You have been studying this now for decades, and this is the thing that struck me, that you all who've been studying this have known that obesity was a disease, at least for the past 10 years.
Dr. Ania Jastreboff 4:42
Yes, yes, yes, we have. Actually, longer than that.

What are the long-term effects and considerations of taking GLP-1s?

Dr. Ania Jastreboff 4:45
OK, longer than that.
Oprah Winfrey 4:46
OK, OK. And how did we all miss the memo?
Dr. Ania Jastreboff 4:53
Well, it's one thing for a medical association to declare obesity as a disease, right? So the AMA declared obesity as a disease in 2013. The WHO declared it as a disease in 1948. And actually, we already knew that obesity was a disease back in Egyptian times. It's another thing to say that it's because of biology and to understand that there's a biology that is driving that obesity.

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