In this episode, we're delving into the fascinating world of sirtuins, exploring their role in countering the 9 hallmarks of cellular aging, and uncovering ways to optimize their activity for our benefit. We'll be exploring 7 proven strategies, backed by scientific research, that can effectively boost the expression of these longevity-promoting sirtuins within the body. Topics: 1. Introduction - Overview of NAD+ and its role in energy metabolism - Previous discussion on strategies to increase NAD+ levels - Importance of NAD+ in other reactions such as those mediated by sirtuins 2. Sirtuins: Introduction and Background - Definition and origin of the term "sirtuins" - Discovery of sirtuins and their role in yeast aging - Transition from yeast cells to mammalian cells - Introduction to SIRT1 as a focus for exploration 3. SIRT1: NAD+-Dependent Histone Deacetylase - Role of SIRT1 as an NAD+-dependent histone deacetylase - Gene silencing / gene expression - SIRT1's influence on "genome stability" mediated by its ability to silence genes 4. SIRT1's Multi-Faceted Activities - Beyond histone deacetylation: SIRT1's reach to non-histone proteins - Deacetylation of p53 and suppression of cellular senescence - Enhancement of telomere integrity - Connecting these activities back to those 9 hallmarks of aging 5. The Sirtuin Enhancement Toolkit for Longevity: 7 Strategies - Resveratrol and Pterostilbene - Increasing NAD+ availability through various methods - Exercise's influence on SIRT1 expression - DHA (Omega-3 fatty acid) and its role in activating SIRT1 - Zinc's importance for SIRT1's structural integrity and function - Nutraceuticals: Berberine, quercetin, fisetin, and curcumin - Intermittent fasting and its impact on NAD+ levels and SIRT1 Thanks for tuning in! If you liked this episode, please leave a rating and review or share it to your stories over on Instagram. If you tag @synthesisofwellness, Chloe would love to personally thank you for listening! Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit ⁠synthesisofwellness.com⁠ to purchase products, subscribe to our mailing list, and more! Or visit ⁠linktr.ee/synthesisofwellness⁠ to see all of Chloe's links, schedule a BioPhotonic Scanner consult with Chloe, or support the show! Thanks again for tuning in!

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“What did the council decide on item 42?” — answered with the speaker and the moment.

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