In Episode 53 of the Total Knee Success podcast, Michelle explains what platelet‑rich plasma (PRP) injections are and how they are used before total knee replacement. She discusses how PRP is prepared from a patient’s own blood, what the research shows about symptom relief for knee osteoarthritis, and why PRP does not reverse advanced structural arthritis. The episode also describes what patients typically experience before and after the injection.What will you do before surgery? You need a clear checklist so you know exactly what to prepare, what to expect, and how to set yourself up for a smoother first week after surgery. totalkneesuccess.kit.com/free2weeklaunchThe Knee Replacement Game Plantotalkneesuccess.comMedical Disclaimer: This podcast is for educational purposes only and does not constitute medical advice. The content is not intended to replace individualized medical guidance, diagnosis, or treatment. Always consult your surgeon, physical therapist, or other qualified healthcare provider regarding your specific condition, surgical decisions, and rehabilitation plan.Amazon Affiliate Disclaimer: Some resources mentioned in this podcast may include Amazon affiliate links. If you choose to purchase through these links, the podcast may earn a small commission at no additional cost to you.Evidence-Based Content Statement: All information presented in this episode is grounded in peer-reviewed research, published clinical guidelines, and current best practices in orthopedic surgery and rehabilitation.Music Licensing Statement: Intro and outro music for the Total Knee Success Podcast is licensed for commercial use. Editing and production for this episode were completed using Descript.References Bannuru RR, Osani MC, Vaysbrot EE, et al. Comparative effectiveness of pharmacologic interventions for knee osteoarthritis: a systematic review and network meta‑analysis. Ann Intern Med. 2015;162(1):46‑54.Dai WL, Zhou AG, Zhang H, Zhang J. Efficacy of platelet‑rich plasma in the treatment of knee osteoarthritis: a meta‑analysis of randomized controlled trials. Arthroscopy. 2017;33(3):659‑670.Belk JW, Kraeutler MJ, Houck DA, et al. Platelet‑rich plasma versus hyaluronic acid for knee osteoarthritis: a systematic review and meta‑analysis of randomized controlled trials. Am J Sports Med. 2021;49(1):249‑260.Filardo G, Di Matteo B, Di Martino A, et al. Platelet‑rich plasma intra‑articular knee injections for the treatment of degenerative cartilage lesions and osteoarthritis. Knee Surg Sports Traumatol Arthrosc. 2015;23(7):1913‑1920.Cole BJ, Karas V, Hussey K, et al. Hyaluronic acid versus platelet‑rich plasma: a prospective, double‑blind randomized controlled trial comparing clinical outcomes in knee osteoarthritis. Am J Sports Med. 2017;45(2):339‑346.Zhao J, Huang H, Liang G, et al. Platelet-rich plasma for knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials. J Orthop Surg Res. 2023;18:518.Shen L, Yuan T, Chen S, Xie X, Zhang C. The temporal effect of platelet‑rich plasma on pain and physical function in the treatment of knee osteoarthritis: systematic review and meta‑analysis of randomized controlled trials. J Orthop Surg Res. 2017;12:16.Laudy ABM, Bakker EWP, Rekers M, Moen MH. Efficacy of platelet‑rich plasma injections in osteoarthritis of the knee: a systematic review and meta‑analysis. Br J Sports Med. 2015;49(10):657‑672.

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