UNTAPPED with Spencer Matthews
The Truth About Peptides: From Ozempic To The Wolverine Stack
28 May 2026
Chapter 1: What is the main topic discussed in this episode?
Hello and welcome to Untapped, the extra mile with me, Spencer Matthews. And me, Olly Patrick. It'll never get old. I just, I do, I love you. I do. I love you. I just think you're great. It's a mutual love. Thank you. This week, we're going to be discussing peptides. You've heard about them, I'm sure. Most people have. They're kind of everywhere, but nowhere.
They kind of fly under the radar, yet they're very present across the board. What are they? And let's discuss them.
That's actually a brilliant description. They're sort of everywhere and nowhere because they're in every conversation to do with health, but no one really knows what the hell they are. And those involved in health and medicine have no idea if they work.
Chapter 2: What are peptides and why are they gaining popularity?
And we've got to separate peptides, peptides. What on earth are we talking about? We're talking about short chain amino acids. And already people are like... What? What's that? But of course, protein is made up of these building blocks, amino acids, and protein is longer chains of amino acids. Peptides are shorter chains of amino acids.
So where there might be two to 50 amino acids bound together, that would be called a peptide. If it gets much longer than that, becomes a really complicated structure, that'd be called a protein. All of that is relatively uninteresting unless you're in sort of molecular biology. But it's confusing, right? Because a peptide can be a hormone. So insulin is a peptide. Isn't that exciting?
It is. I'm already enthralled but lost, you know, because, you know, just for the record, I'm not a chemist. Nor am I, you know, I can't really remember. I don't really remember school. This is a separate thing, right? But like, if you were to ask me... Anything that I learned at school, I might struggle to answer that question, to be honest. You know, I always say I live in the moment.
It almost is like anything that happened before this moment is gone, right? So talk to me as if you were talking to like a really young child or like a dog or something, right? Okay. I don't understand any of this. So I know that protein is good. And you're saying that if the chain is slightly shorter, you're in peptide territory. And that is it.
But why would some people then consider, and I think this is quite a few people, lots of people would just hear the word peptides and go, dangerous. Protein though, load up on it.
Totally normal. And because it's such a confusing topic, because peptide is too big a term. So when someone says I'm talking about peptides, which peptide are you talking about and why? The one that lots of people will be hearing about will be GLP-1, glucagon-like peptide, something your gut produces naturally. It's called an incretin hormone. That's like a Zempik. Zempik.
I don't want to come back to that because that's probably the most publicly explained, but that's a peptide. And there'll be another peptide that does a sort of a strange role in the body that we don't yet fully understand. What we've got is the peptides most people are talking about
are these potentially off-license therapeutic peptides that the well-being and longevity community have started jacking up on, injecting, and injecting for good reason. They don't necessarily make it through the old tummy acid.
So people are injecting these peptides on the basis they believe they're going to get some kind of passive significant health benefit, which as we sit here now, pal, is massively unproven. The rise of the glucagon-like 1 peptide, so a Zempik was the sort of first
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Chapter 3: How do GLP-1 peptides like Ozempic and Manjaro work?
Were you to be training for any kind of performance, I can't imagine that any of these things are that helpful. Because unless, like, I'm trying to ascertain basically whether, because I like the idea of all this stuff. I hear about Retta on podcasts. I have friends that take Retta, right? And they're just like, it's dynamite. Everything about it is fantastic. I feel fantastic. I sleep well.
I've lost weight. I haven't lost any muscle. I'm a beast. I feel like Wolverine. It's all kinds of stuff that I hear about Retta, for example. I'm sure it's probably similar for Monjaro and the others, but Retta's the new shiny toy in peptides. And it's kind of, I... You can't help but think, well, that sounds fun. I'm into that, right?
But if you're able to control your calories anyway, and you're pushing yourself to train hard anyway, and you're eating your protein, and you don't snack much, and you do have good discipline, is it...
healthy to take this or is it literally just a kind of mental curvature of the desire to eat more if i need a significant volume of carb loading for my glycogen stores and i need a significant volume of protein and i've got to get on it's gonna be difficult to ratify a high training volume with that caloric restriction and that lack of desire to eat. So these are unknowns, right?
Because these drugs weren't built for that audience. They're being repurposed. So Retatrutai, which you know is not on license in the UK yet. It's being made by Eli Lilly. It should be coming here fairly soon. And people call it GLP-3. It's not technically true, but it's three mechanisms of action.
Is it... better than the other? So when, you know, obviously I have no idea how pharmaceutical companies operate or work, but you take an azenpic, is Manjaro essentially better and safer than azenpic? And is Reta essentially better and safer than Manjaro? Well, safer is more about
how many people have taken it for how long you know clearly they have to pass their tests to get drugs you know through the human trials and out into the mainstream semi-glutide first drug it might have lost you 20 25 of your weight in a year then they said well we can add to the semi-glutide um so the glp-1 will add something else called gip so i had two mechanisms of suppressing appetite
controlling glucose. And so Manjaro was the brand for the second iteration that was a bit more effective. Maybe that's 25, I can't remember the figures, 25 or 30% of your weight. So more effective, but less people have tried it. Retrotrutide coming out is three mechanisms of action.
So it's got the original GLP-1, it's got another one, GIP, and then it's got glucagon, which is a hormone that helps. This is all about stabilizing the glucose in your bloodstream.
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Chapter 4: What are the potential risks of using peptides for weight loss?
And for me, if it's not governed by a physician, I wouldn't touch it.
Thank you, Ollie. I think we could do another episode on peptides. I find that really fascinating because we're out of time for this particular episode, but we haven't gone into... peptides that help hair regenerative growth and nails and skin and things that are more aesthetic than others. And I think by the sounds of things, there's pretty much a peptide for everything.
So there's probably another conversation that we could have, I think, on peptides. We dwelled a lot on the weight loss side of things today, but it's been really fascinating. I'm more about it. It remains very interesting. And we hope that you learned something about peptides here today as well. Enjoy whatever you're doing. And yeah, be safe, kids. Chat to your doctor.
If you've enjoyed this conversation and you'd like to hear more about peptides, perhaps there's some specific peptides that you'd like us to go into, drop your questions in the comments and we will come back to you. And we would be happy to do a follow-up episode specific to your requirements.