Calley Means
speaker
1,357 appearances
15 recordings
7 series
first heard Oct 2024
last heard 9 Apr
Calley Means’s voice in public audio — every appearance, attributed to the second.
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recordings per month · last 12 monthsRecordings per month over the last 12 months — 2 in all, peaking in Apr 2026 with 1.
Appearances
We're dealing with the metabolic disease epidemic, which is the leading driver of mortality in In the Western world now, we like to call all these different metabolic diseases by different names, which may make them artificially seem like they have less impact. But really, like you said, the root cause is a problem with metabolism.
When we talk about obesity, diabetes, heart disease, stroke, Alzheimer's, dementia, fatty liver disease. It's we know that all of these are related to dysregulated blood sugar. And in fact, nine of the 10 leading causes of death in the United States are in some way either directly caused by or worsened and accelerated by dysregulated blood sugar.
So to get to this question of what are the foods we need to avoid? void in order to prevent these diseases, one of the biggest things we need to do is keep our blood sugar in a stable and healthy range throughout the entirety of our lifetimes.
And we have the power to do that by making smart choices about our foods and, of course, also pulling the other levers that impact our blood sugar, which is, of course, exercise, sleep, stress management, optimizing our microbiome. avoidance of environmental toxins that hurt our metabolic pathways.
I would say that the foods that drive these cardiometabolic diseases are foods that disrupt our cells from doing what they need to do to function optimally and that then lead to insulin resistance, the physiologic process that ultimately creates the dysregulated blood sugar. The reality is that the average American wants to be healthy and is putting in work to try to be healthy.
We see that 50% of American adults go on a diet every year trying to lose weight. Of course, 72% of Americans right now are overweight or obese, but half the country is making the commitment and reporting that in a survey saying that they're trying to lose weight. And yet every year we are getting sicker, we are getting fatter, we are getting more anxious.
So there's clearly an effort outcome mismatch. And that's where I think the future.
Yeah, effort outcome mismatch. Yeah, that's a good way to talk about it. Right.
And that is where I think tools that can empower people with information to actually make choices that actually impact the physiology that leads to chronic disease and weight gain is really going to shape and change the future of health care and really create this patient empowered, more decentralized form of health care.
where we don't just outsource our judgment to other people, to the food companies, to healthcare systems that give very generic recommendations to anyone. We actually are able to have the judgment about our bodies for ourselves. And I think that's pretty cool.
It has been so incredible to start to see some trends emerge from this huge, anonymized, aggregated data set, really the first of its kind in the world. Like you mentioned, we have 51 million glucose data points, and this is just amongst our closed beta program, 16,000 people who have gone through our closed beta program.
We have almost 200,000 people on our wait list, so you can imagine that 51 million is data points is going to get a lot larger when we start opening to more people. We have those 51 million glucose data points paired with 1.3 million food logs. We can start to see for the first time ever how specific foods across a population
are affecting, uh, glucose and, and creating this population data of a closed loop biofeedback. Um, you mentioned the individualized aspect of this. That is so true. And that paper that you referenced, um, personalized nutrition by prediction of glycemic responses that was done about five years ago in Israel showed how variable it is person to person.
Uh, we could both of course, eat the exact same cookie and you and I could have a very different glucose response based on several factors like our microbiome, our underlying insulin resistance, et cetera. That's a really important aspect is for the individual, what kind of data they can get to really truly personalize their own data based on glucose response because of course,
we talked about this a lot in our last episode a more stable glucose level with more gentle rolling hills after meals avoiding the huge spikes and valleys that we see after eating large amounts of carbohydrates and sugar that's what we want we want the gentle rolling hills the low glucose response so you can start to see that in yourself and shape your diet very quickly on the population level
then we get to see something interesting as well that actually can benefit anyone, not just the people who have a sensor on. Because this becomes a database that really informs the nutrition industry like we've never been able to before, where we start to see radical transparency about what food is actually doing to people's bodies.
And I personally think in five years, it's going to seem incredibly outdated, incredibly quaint to walk into the grocery store and choose foods based on what the box says, based on interests that are not aligned with your thriving and well-being. They're aligned with taking you to your bliss point, making you dependent.
for it, making your dopaminergic reward systems want to keep coming back, but it's not aligned necessarily with your health. And so we're going to start to see this huge new way of choosing foods. I can imagine, you know, like a person with polycystic ovarian syndrome, for instance, a condition that we know is directly related to insulin resistance.
And studies have shown that low carb diets, a healthy Mediterranean ketogenic diet for just 12 weeks can actually reverse PCOS. This was a study done just a couple of years ago. So there's people, and women are very savvy with their research, and they're going out and they're reading the books, they're reading these papers, and they know they need to keep their glucose and insulin under control.
They know that just being prescribed a birth control pill and metformin is not the answer to their long-term health. And so they're looking for tools. And you can imagine that woman, her doctor says to her, oh, you don't have diabetes. You don't need to worry about blood sugar. You have PCOS. It's very different. They know, though. They've read. They do their research.
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