Dave Asprey
speaker
17,208 appearances
48 recordings
1 series
first heard May 2026
last heard 14 Aug
Dave Asprey’s voice in public audio — every appearance, attributed to the second.
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recordings per month · last 12 monthsRecordings per month over the last 12 months — 48 in all, peaking in Jul 2026 with 18.
Appearances
We've spent a decade watching amyloid clearing drugs like Lokembi get approved with marginal benefits and real safety concerns, mostly because they only work on a narrow slice of patients carrying a specific gene.
Phenonet is taking a decades-old, dirt cheap, extremely well understood molecule and asking a smarter question.
Does inflammation and microglial cleanup matter more than we've been told?
I've argued for years that neuroinflammation drives cognitive decline as much as plaque does, and this trial design is basically betting on that same idea.
Doctors have historically told non-APOE4 carriers there's not much on offer for them.
This is a signal that might change.
If Alzheimer's runs in your family, get your APOE4 status tested now so you know exactly which trials and treatments.
will apply to you when they land.
Next up, researchers at the University of Zurich just found a group of cells they're calling regenerative astrocytes, and what they do is genuinely wild.
Astrocytes are the support cells that feed your neurons and keep brain tissue healthy.
And the old assumption was that once you lose a bunch of them to injury or disease, the adult brain can't really replace them.
Turns out that's wrong.
These regenerative astrocytes gather around the edge of damaged tissue, divide, and then send the new nuclei from their daughter cells traveling across long distances through their own extensions to repopulate the injury site and knit the whole network back together.
The working assumption in neurology has been that adult brain damage is mostly permanent.
You manage it, you don't reverse it.
This says the brain already has a repair system built in.
The researchers also mapped out the genes and signaling pathways that switch on during this process, which means there's now a target list for anyone trying to figure out how to boost this repair mechanism on purpose instead of waiting for the brain to do it on its own timeline.
If you're dealing with any kind of brain injury or recovery, don't let anyone tell you the damage is simply permanent.
Push for the most current research on regenerative therapies before you accept that as the final word.
Another fun story here.
Showing 21–40 of 17,208 · page 2 of 861
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