TED Talks Daily
What to do when you’re told there’s nothing left to try | David Fajgenbaum and Kiah Williams
20 to 30% of all prescriptions in the US every day are off-label, so doctors are trying drugs for diseases they're not intended for.
TED Talks Daily
What to do when you’re told there’s nothing left to try | David Fajgenbaum and Kiah Williams
Unfortunately, it happens very randomly, and there are a lot more opportunities for those drugs to be used systematically, but it's just not profitable in our system to find a new use for an old drug.
TED Talks Daily
What to do when you’re told there’s nothing left to try | David Fajgenbaum and Kiah Williams
80% of drugs are generic, so unfortunately, the system isn't built for this.
TED Talks Daily
What to do when you’re told there’s nothing left to try | David Fajgenbaum and Kiah Williams
to find new uses for medicines.
TED Talks Daily
What to do when you’re told there’s nothing left to try | David Fajgenbaum and Kiah Williams
But the reason I share that as background is that that means that most of you all have received a drug for a disease it wasn't intended for.
TED Talks Daily
What to do when you’re told there’s nothing left to try | David Fajgenbaum and Kiah Williams
And maybe it helped some of you.
TED Talks Daily
What to do when you’re told there’s nothing left to try | David Fajgenbaum and Kiah Williams
You can go to everycure.org slash ideas and you can tell us about a drug that you've received that maybe has helped you that we can look into.
TED Talks Daily
What to do when you’re told there’s nothing left to try | David Fajgenbaum and Kiah Williams
We can look into our AI platform to see how is it ranking versus all of our other repurposing ideas.
TED Talks Daily
What to do when you’re told there’s nothing left to try | David Fajgenbaum and Kiah Williams
Second is that you can help to support us financially.
TED Talks Daily
What to do when you’re told there’s nothing left to try | David Fajgenbaum and Kiah Williams
We run large clinical trials that are very expensive, and we want to reach patients all over the world.
TED Talks Daily
What to do when you’re told there’s nothing left to try | David Fajgenbaum and Kiah Williams
And finally, awareness raising is really important.
TED Talks Daily
What to do when you’re told there’s nothing left to try | David Fajgenbaum and Kiah Williams
We find treatments for diseases that we never would have imagined, like lidocaine for breast cancer or DFMO for Bachman-Bupp syndrome.
TED Talks Daily
What to do when you’re told there’s nothing left to try | David Fajgenbaum and Kiah Williams
And amazingly, the problem for a lot of these medications is just awareness, just getting that drug to the patient.
TED Talks Daily
What to do when you’re told there’s nothing left to try | David Fajgenbaum and Kiah Williams
It's a matter of letting patients and doctors know, so helping to spread the word about our work at EveryCure.
TED Talks Daily
What to do when you’re told there’s nothing left to try | David Fajgenbaum and Kiah Williams
Sure, I think there's three things that can really help you during a really tough time.
TED Talks Daily
What to do when you’re told there’s nothing left to try | David Fajgenbaum and Kiah Williams
And I learned this from the six months that I spent in the intensive care unit when I was dying from my disease, Castleman's.
TED Talks Daily
What to do when you’re told there’s nothing left to try | David Fajgenbaum and Kiah Williams
And the first is that you have to have a vision for what you're fighting for.
TED Talks Daily
What to do when you’re told there’s nothing left to try | David Fajgenbaum and Kiah Williams
So you have to
TED Talks Daily
What to do when you’re told there’s nothing left to try | David Fajgenbaum and Kiah Williams
be able to actually see what is it that you want and that you're wishing and hoping for.
TED Talks Daily
What to do when you’re told there’s nothing left to try | David Fajgenbaum and Kiah Williams
So for me, I was wishing and hoping for a family with my girlfriend at the time, Caitlin.