David Friedberg
speaker
8,052 appearances
60 recordings
4 series
first heard Apr 2024
last heard 21 Aug
David Friedberg’s voice in public audio — every appearance, attributed to the second.
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recordings per month · last 12 monthsRecordings per month over the last 12 months — 32 in all, peaking in Jan 2026 with 6.
Appearances
I followed him.
So Sinclair is kind of bemoaned a little bit by the scientific and academic community for being a little too overhypey, snake oil salesman, as some folks have claimed.
Because years ago, he sold a company to GSK saying resveratrol would reverse aging.
And, you know, he made $720 million on that.
It didn't end up working.
And he's promoted certain supplement companies and so on.
So I want to preface with that before I kind of underwrite what he's saying with this next thing.
But he's a co-founder of a company called Life Biosciences.
And they've reached a major agreement with the FDA to be the first company to treat humans with Yamanaka factors.
Specifically what they're doing is they're going to be delivering these Yamanaka factors.
These are these proteins.
that rejuvenate cells and make them youthful again into the eye.
And so their first indication is to actually inject them into the vitriol fluid in the eyeball, and they'll affect the retina in the eye to address people that have gotten blind from glaucoma or one of these kind of stroke-like diseases that happen in the eye.
And the expectation with this phase one clinical trial is that the delivery of these Yamanaka factors into the eye
will rejuvenate the retina, make it youthful again, and restore vision.
If it works, which it's expected to, because we see this result happen in animal models, it could be an extraordinary breakthrough, not just in terms of blindness, but in terms of the first human application of Yamanaka factors to reverse aging.
The way they're doing it is they're actually packaging up DNA that will make these proteins into viruses, AAV virus, that is delivered into the eye.
The virus will then go into the retinal cells and then will deliver this payload for this DNA to make these proteins in the eye cells.
And it can be turned on and off.
Amazingly, they've created a switch mechanism in it
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